The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Anticoagulant Activity of Gleditsiae Spina Extract

조각자(皂角刺)추출물의 항응혈 활성

  • Yoo, Ji-Hyun (Dept. of Oriental Medicine Resources, Joongbu University) ;
  • Jung, Bung-Tea (Dept. of Oriental Medicine Resources, Joongbu University) ;
  • Kil, Gi-Jung (Dept. of Oriental Medicine Resources, Joongbu University)
  • 유지현 (중부대학교 한약자원학과) ;
  • 정봉태 (중부대학교 한약자원학과) ;
  • 길기정 (중부대학교 한약자원학과)
  • Received : 2010.02.16
  • Accepted : 2010.03.22
  • Published : 2010.03.30
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Abstract

Objectives : This research was investigated the anticoagulant effect of the Gleditsiae spina extract. Methods : We researched prothrombin time (PT) assay, activated partial thromboplastin time (APTT) assay in vitro and in vivo using arteriovenous (A-V) shunt rat model and shortening Rat tail bleeding time (BT). A-V shunt and BT were treated with extract of Gleditsiae spina (GS) 400 mg/kg for a week. Results : Bleeding time of Gleditsiae spina extract in vivo had a significant increase as about 1.2 times and thrombus weight of Gleditsiae spina extract had a significant reduction of thrombus weight as 26%. Gleditsiae spina extract represented an effect of anticoagulation by operating on extrinsic pathway factor II, V, VII, X and intrinsic pathway factor VIII, IX, X, XI, XII in the coagulation system. Conclusions : Considering the above mentioned results, it is judged that a Gleditsiae Spina extract has a control effect of thrombus creation.

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References

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