The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of NR on Production Levels of Cytokines and Distribution of BAL Cells in Allergic Asthma

강활추출물이 알레르기 천식 모델 생쥐에 기관지폐포세척액의 면역세포에 미치는 영향

  • Bae, Jin-Hyun (Dept. of Oriental Medicine Resources, Joongbu University) ;
  • Yoo, Ji-Hyun (Dept. of Oriental Medicine Resources, Joongbu University) ;
  • Kil, Gi-Jung (Dept. of Oriental Medicine Resources, Joongbu University)
  • 배진현 (중부대학교 한약자원학과) ;
  • 유지현 (중부대학교 한약자원학과) ;
  • 길기정 (중부대학교 한약자원학과)
  • Received : 2010.02.12
  • Accepted : 2010.03.22
  • Published : 2010.03.30
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Abstract

Objectives : This study was designed to investigate therapeutic effects fo NR on allergic asthma in terms of measurement of cytokine profiles, distribution of BAL and expression levels of asthma induced by OVA. Methods : C57BL/6 mouse was divided into normal, NRI, control, and NRII, and Notopterygii Rhizoma Extract was orally administered to the C57BL/6 mice in the normal group and the normal mouse in NRI group while it was orally administered to the control group after inducing asthma by OVA and NRII. The study measured them by means of ELISA after dividing BALF of each group, and analyzed RT-PCR by using lung tissues. Results : In our results, lung weight and the number of total cells in the lung and of Leukocyte and Eosinophils in BALF were significantly decreased. In addition, IL-4, IL-5, IL-13, and IgE in BALF were significantly decreased compared to the control group. Conclusions : These results demonstrate that NR Extract be a desirable altemative therapy for allergic asthma by inhibiting the expressin of immune cells, the activation of inflammatory mediator.

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