생약학회지 (Korean Journal of Pharmacognosy)

  • 제41권1호
  • /
  • Pages.38-42
  • /
  • 2010
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

MRSA에 대한 울금 추출 및 분획물의 항균활성과 항생제 증강 효과

Antibacterial Activity and Enhancing Antibiotic Effect of Extract and Fractions from Curcuma longa against MRSA Strain

  • 이경인 (동신대학교 생물자원산업화지원센터) ;
  • 최철희 (조선대학교 의과대학 내성세포연구센터) ;
  • 김선민 (동신대학교 한약재산업학과) ;
  • 표병식 (동신대학교 한약재산업학과)
  • Lee, Kyoung-In (Biotechnology Industrialization Center, Dongshin University) ;
  • Choi, Cheol-Hee (Research Center for Resistant Cells, Dept. of Pharmacology, Chosun University) ;
  • Kim, Sun-Min (Dept. of Oriental Medicine Materials, Dongshin University) ;
  • Pyo, Byoung-Sik (Dept. of Oriental Medicine Materials, Dongshin University)
  • 투고 : 2009.11.15
  • 발행 : 2010.03.31
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초록

Curcumin content of butanol fraction from C. longa was found to be 22.4942% of the highest content. However, in DPPH radical scavenging ability and antibacterial activity against methicillin resistance Staphylococcus aureus(MRSA, CCARM3696), ethylacetate fraction contained 2.5791% of curcumin was exhibited highest activity. In comparison of enhancing antibiotic(ampicillin) effect against MRSA, ethanol extract contained 1.7838% of curcumin showed more strong activity. This indicates that the ethanol extract and some fractions from C. longa can have antibacterial activity and enhancing antibiotic effect possibly without curcumin. Appropriate use of antimicrobial agent was important point prior to the development of new antibiotics. And in that sence, extract and fractions of C. longa were worth using as synergist of antibiotics and natural antimicrobial agent.

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