생약학회지 (Korean Journal of Pharmacognosy)

  • 제41권1호
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  • Pages.31-37
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  • 2010
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

배암차즈기(Salvia plebeia R.) 추출물의 항염 및 항 알레르기 효과

A Study on the Anti-inflammatory and Anti-allergic Effect of Salvia plebeia R. extracts

  • 투고 : 2010.02.17
  • 발행 : 2010.03.31
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초록

The Salvia plebeia R. which is the biennial plant belonging to the Labiatae department, grows naturally in the Korea entire area. Presently, its extract (SPRE) is known to have an anti-inflammation and anti-allergy activity, but there are a few evidences about it. SPRE inhibits pro-inflammatory cytokine such as TNF-$\alpha$ and IL-6 as well as nitric oxide (NO) production in lipopolysaccharide (LPS) treated- macrophages. The co-administration of SPRE during OVA sensitization significantly reduced total IgE levels in mice. The mice who received SPRE co-administered with OVA showed a significant increase in serum OVA-specific IgG2a/b levels. Spleen-cell cultures harvested from OVA-sensitized mice showed a significant decrease in Th2 cytokine levels with a concomitant increase in Th1 cytokine levels only when SPRE co-administered with OVA. These results demonstrate that SPRE can control the LPS-induced inflammatory reaction and prevent antigen-induced Th2 immune responses in mice.

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참고문헌

  1. Lee, H. J., Kang, G, J., Yoon, W, J., Kang, H, K., Kim, Y, S., Kim, S, M. and Yoo, E, S. (2006) Anti-inflammatory Effect of Unripe Fruit of Citrus grandis Osbeck in RAW 264.7 and HaCaT Cells. Kor. J. Pharmacogn. 37: 74-810.
  2. Chang, L. P., Lai, Y. S., Wu, C. J. and Chou, T. C. (2009) Liquid perfluorochemical inhibits inducible nitric oxide synthase expression and nitric oxide formation in lipopolysaccharidetreated RAW 264.7 macrophages. J. Phaarmacol. 111: 147-154.
  3. Isolauri, E., Huurre, A., Salminen, S. and Impivaara, O. (2004) The allergy epidemic extends beyond the past few decades. Clin. Exp. Allergy 34: 1007-1010. https://doi.org/10.1111/j.1365-2222.2004.01999.x
  4. Arancibia, S. A., Beltran, C. J., Aguirre, I. M., Silva, P., Peralta, A. L., Malinarich, F. and Hermoso, M. A. (2007) Tolllike receptors are key participants in innate immune responses. Biol. Res. 40: 97-112.
  5. Leon, B. and Ardavin, C. (2008) Monocyte-derived dendritic cells in innate and adaptive immunity. Immunol. Cell Biol. 86: 320-324. https://doi.org/10.1038/icb.2008.14
  6. Chinen, J. and Shearer, W. T. (2008) Advances in basic and clinical immunology in 2007. J. Allergy Clin. Immunol. 122:3 6-41. https://doi.org/10.1016/S0091-6749(08)02070-8
  7. Brandtzaeg, P. E. (2002) Current understanding of gastrointestinal immunoregulation and its relation to food allergy. Ann. NY Acad. Sci. 964: 13-45.
  8. Yoon, T. J. (2008) Effect of water extracts from root of Taraxacum officinale on innate and adaptive immune response in mice. Korean J. Food & Nutr. 21: 275-282.
  9. Lim, J. A., Yun, B. W. and Baek, S. H. (2007) Antioxidative Activity and Nitrite Scavenging Ability of Methanol Extract from Salvia plebeia R. Br. Korean J. medicinal Crop Sci. 15: 183-188.
  10. Jeon, H. J., Kang, H. J., Jung, H. J., Kang, Y. S., Lim, C. J., Kim, Y. M. and Park, E. H. (2007) Anti-inflammatory activity of Taraxacum officinale. J. Ethnopharmcol. 115: 82-88.
  11. Choi Y., Park, S. K., Kim, H. M., Kang, J. S., Yoon, Y. D., Han, S. B., Han, J. W., Yang, J. S. and Han, G. (2008) Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model. Exp. Mol. Med. 40: 574-581. https://doi.org/10.3858/emm.2008.40.5.574
  12. Dai, Y., Chan, Y. P., Chu, L. M. and Bu, P. P. (2002) Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis. Biol. Pharm. Bull. 25: 1179-1182. https://doi.org/10.1248/bpb.25.1179
  13. Dearman., R, J., Skinner, R. A., Herouet, C., Labay, K., Debruyne, E. and Kimber, I. (2003) Induction of IgE anti-body responses by protein allergens: inter-laboratory comparisons. Food Chem. Toxicol. 4: 1509-1516.
  14. Kenny, T. P., Keen, C. L. and Schmitz, H. H., Gershwin, M. E. (2007) Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells. Exp. Biol. Med. 232: 293-300.
  15. Bennett, B., Check, I. J., Olsen, M. R. and Hunter, R. L. (1992) A comparison of commercially available adjuvants for use in research. J. Immunol. Methods 153: 31-40. https://doi.org/10.1016/0022-1759(92)90302-A
  16. Medeiros, K. C., Figueiredo, C. A., Figueredo, T. B., Freire, K. R., Santos, F. A., Alcantara-Neves, N. M., Silva, T. M. and Piuvezam, M. R. (2008) Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice. J. Ethnopharmacol. 119: 41-46. https://doi.org/10.1016/j.jep.2008.05.036
  17. Vasilakos, J. P., Smith, R. M., Gibson, S. J., Lindh, J. M., Pederson, L. K., Reiter, M. J., Smith, M. H. and Tomai, M. A. (2000) Adjuvant activities of immune response modifier R-848: comparison with CpG ODN. Cell Immunol. 204: 64-74. https://doi.org/10.1006/cimm.2000.1689
  18. Takano, F., Takata, T., Yoshihara, A., Nakamura, Y., Arima, Y. and Ohta, T. (2007) Aqueous extract of peanut skin and its main constituent procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin. Biol. Pharm. Bull. 30: 922-7. https://doi.org/10.1248/bpb.30.922
  19. Park, Y., Chang, Y. S., Lee, S. W., Cho, S. Y., Kim, Y. K., Cho, S. H. and Sung, Y. C. (2001) The enhanced effect of a hexameric deoxyriboguanosine run conjugation to CpG oligodeoxynucleotides on protection against allergic asthma. J. Allergy Clin. Immunol. 108: 570-576. https://doi.org/10.1067/mai.2001.118517
  20. Dredge, K., Marriott, J. B., Todryk, S. M. and Dalgleish, A. G. (2002) Adjuvants and the promotion of Th1-type cytokines in tumour immunotherapy. Cancer Immunol. Immunother. 51: 521-531. https://doi.org/10.1007/s00262-002-0309-z
  21. Zhu, F. G., Kandimalla, E. R., Yu, D., Tang, J. X. and Agrawal, S. (2004) Modulation of ovalbumin-induced Th2 responses by second-generation immunomodulatory oligonucleotides in mice. Int.. Immunopharmacol. 4: 851-862. https://doi.org/10.1016/j.intimp.2004.03.009