Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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The First Case of Novel Influenza A (H1N1) Fatality in Korea

  • Seol, Hee-Yun (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Eom, Jung-Seop (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Kim, Mi-Hyun (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Cho, Woo-Hyun (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Kim, Ji-Eun (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Kim, Ki-Uk (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Jeon, Doo-Soo (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Park, Hye-Kyung (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Kim, Yun-Seong (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Lee, Min-Ki (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Park, Soon-Kew (Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine)
  • Received : 2009.12.31
  • Accepted : 2010.02.08
  • Published : 2010.06.30
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Abstract

Here we report the first fatality caused by H1N1 influenza virus infection with acute respiratory distress syndrome in Korea. A 55-year-old man presented at our emergency department with dyspnea, fever, diffuse myalgia and malaise. Bilateral lung air-space consolidation was detected on his initial chest radiograph combined with severe hypoxemia. He was supported by mechanical ventilation and treated with antibiotics. A nasopharyngeal aspirate was positive for influenza A rapid antigen and oseltamivir was started on day 3 of admission. The nasal swab sample was positive for influenza H1N1 virus by real-time reverse-transcriptase polymerase chain reaction. Despite aggressive treatment, he had refractory hypoxemia and uncontrolled septic shock. On day 5 of admission he went into cardiac arrest and expired.

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References

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