Atypical Nodular Granulomatous Episclerokeratitis in a Dog

개에서 발생한 비정형의 결절성 육아종성 상공막염 1례

  • Kim, Tae-Hyun (Department of Veterinary Ophthalmology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Jeong, Man-Bok (Department of Veterinary Ophthalmology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Park, Shin-Ae (Department of Veterinary Ophthalmology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Kim, Won-Tae (Department of Veterinary Ophthalmology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Kim, Se-Eun (Department of Veterinary Ophthalmology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Park, Young-Woo (Department of Veterinary Ophthalmology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Ahn, Jae-Sang (Department of Veterinary Ophthalmology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Kim, Hyung-Jin (Department of Veterinary Pathology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Chang, Jin-Hwa (Department of Veterinary Medical Imaging, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Kim, Dae-Yong (Department of Veterinary Pathology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Yoon, Jung-Hee (Department of Veterinary Medical Imaging, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University) ;
  • Seo, Kang-Moon (Department of Veterinary Ophthalmology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University)
  • 김태현 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.안과학교실) ;
  • 정만복 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.안과학교실) ;
  • 박신애 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.안과학교실) ;
  • 김원태 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.안과학교실) ;
  • 김세은 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.안과학교실) ;
  • 박영우 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.안과학교실) ;
  • 안재상 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.안과학교실) ;
  • 김형진 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.병리학교실) ;
  • 장진화 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.영상의학교실) ;
  • 김대용 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.병리학교실) ;
  • 윤정희 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.영상의학교실) ;
  • 서강문 (서울대학교 수의과대학.BK21 수의과학연구인력양성사업단.안과학교실)
  • Published : 2010.02.28

Abstract

A 5-year-old castrated male Cocker Spaniel was referred to Veterinary Medical Teaching Hospital of Seoul National University with a history of chronic conjunctival hyperemia and a fleshy corneal mass in the right eye. On ophthalmic examinations, it was observed that a well-vascularized fleshy mass at the dorsolateral limbus extended into the clear cornea. The lesion regressed by initial medications, including both topical and systemic corticosteroids, and topical cyclosporine A. However, the lesion relapsed and grossly infiltrated to cornea in a short period of time without improvement in spite of the immunosuppressive therapy, leading to the vision loss. The eye was enucleated and nodular granulomatous episclerokeratitis was confirmed on histopathological examination.

Keywords

References

  1. Bellhorn RW, Henkind P. Ocular nodular fasciitis in a dog. J Am Vet Med Assoc 1967; 150: 212-213.
  2. Breaux CB, Sandmeyer LS, Grahn BH. Immunohistochemical investigation of canine episcleritis. Vet Ophthal 2007; 10: 168-172. https://doi.org/10.1111/j.1463-5224.2007.00528.x
  3. Dugran SJ, Ketring KL, Severin GA, Render JA. Variant nodular granulomatous episclerokeratitis in four dogs. J Am Anim Hosp Assoc 1993; 29: 403-409.
  4. Gilger BC, Bentley E, Ollivier FJ. Diseases and surgery of the canine cornea and sclera. In: Veterinary ophthalmology, 4th ed. Ames: Blackwell Publishing. 2007: 690-752.
  5. Gwin RM, Gelatt KN, Jr RLP. Ophthalmic nodular fasciitis in the dog. J Am Vet Med Assoc 1977; 170: 611-614.
  6. Hemady R, Tauber J, Foster CS. Immunosuppressive drugs in immune and inflammatory ocular disease. Surv Ophthalmol 1991; 35: 369-385. https://doi.org/10.1016/0039-6257(91)90186-J
  7. Latimer CA, Wyman M, Szymanski C, Winston SM. Azathioprine in the management of fibrous histiocytoma in two dogs. J Am Anim Hosp Assoc 1983; 19: 155-158.
  8. Maggs DJ. Cornea and sclera. In: Slatter's fundamentals of veterinary ophthalmology. 4th ed. Missouri: Saunders Elsevier. 2008: 175-202.
  9. Park SA, Jeong MB, Kim WT, Kim SE, Park YW, Jee H, Kim DY, Seo KM. Episcleritis in dogs: 12 cases. J Vet Clin 2008; 25: 415-419.
  10. Paulsen ME, Lavach JD, Snyder SP, Severin GA, Eichenbaum JD. Nodular granulomatous episclerokeratitis in dogs: 19 cases (1973-1985). J Am Vet Med Assoc 1987; 190: 1581-1587.
  11. Ramsey DT. The sclera, episclera and corneoscleral limbus. In: BSAVA manual of small animal ophthalmology. 2nd ed. British small animal veterinary association. 2002: 156-161.
  12. Regnier A. Antimicrobials, antiinflammatory agents, and antiglaucoma drugs. In: Veterinary ophthalmology, 4th ed. Ames: Blackwell Publishing. 2007: 288-331.
  13. Smith JS, Bistner S, Riis R. Infiltrative corneal lesions resembling fibrous histiocytoma: clinical and pathologic findings in six dogs and one cat. J Am Vet Med Assoc 1976; 169: 722-726.