Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Effect of Limited Oxygen Supply on Coenzyme $Q_{10}$ Production and Its Relation to Limited Electron Transfer and Oxidative Stress in Rhizobium radiobacter T6102

  • Seo, Myung-Ji (Division of Bio.New Drug Development, Central Research Institute, Chem Tech Research Incorporation (C-TRI)) ;
  • Kim, Soon-Ok (Division of Bio.New Drug Development, Central Research Institute, Chem Tech Research Incorporation (C-TRI))
  • Published : 2010.02.28
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Abstract

Coenzyme $Q_{10}$ ($CoQ_{10}$) production from Rhizobium radiobacter T6102 was monitored under various oxygen supply conditions by controlling the agitation speeds, aeration rates, and dissolved oxygen levels. As the results, the $CoQ_{10}$ production was enhanced by limited oxygen supply. To investigate whether the $CoQ_{10}$ production is associated with its physiological functions of electron carrier and antioxidant, the effects of sodium azide and hydrogen peroxide on the $CoQ_{10}$ production were studied, showing that the $CoQ_{10}$ contents were slightly enhanced with increasing sodium azide (up to 0.4 mM) and hydrogen peroxide (up to $10\;{\mu}M$) concentrations. These results suggest the plausible mechanism where the limited electron transfer stimulating the environments of limited oxygen supply and oxidative stress could accumulate the $CoQ_{10}$, providing the relationship between the $CoQ_{10}$ physiological functions and its regulation system.

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References

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