Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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The Inhibitory Effect of Bamboo Culm Extract on the Development of Pulmonary Inflammation in Pristane-Induced Lupus Mice

  • Received : 2010.10.13
  • Accepted : 2010.11.25
  • Published : 2010.12.31
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Abstract

Pulmonary pathogenesis in lupus is characterized by interstitial inflammation and vasculitis in lungs. We investigated whether bamboo culm extract (BC) attenuates pulmonary inflammation and lung injury in pristane-induced lupus mice. The pristane-induced lupus mice and healthy mice were administrated with BC 0.5 ml/kg or PBS orally once a day for 14 days. Our results demonstrated that BC significantly attenuated levels of bronchoalveolar lavage (BAL) IL-6, IL-10, IFN-$\gamma$, $PGE_2$ and VEGF, and pulmonary vascular permeability in pristane-induced lupus mice. Therefore, these findings suggest that BC may inhibit development of pulmonary inflammation and lung injury in lupus.

Keywords

References

  1. Akaogi, J., Nozaki, T., Satoh, M., and Yamada, H., Role of $PGE_2$ and EP receptors in the pathogenesis of rheumatoid arthritis and as a novel therapeutic strategy. Endocr. Metab. Immune. Disord. Drug Targets 6(4), 383-394 (2006). https://doi.org/10.2174/187153006779025711
  2. Al-Mutairi, S., Al-Awadhi, A., Raghupathy, R., Al-Khawari, H., Sada, P., Al-Herz, A., and Rawoot, P., Lupus patients with pulmonary involvement have a pro-inflammatory cytokines profile. Rheumatol. Int. 27(7), 621-630 (2007). https://doi.org/10.1007/s00296-006-0268-3
  3. Anderson, B.O. and Harken, A.H., Multiple organ failure: inflammatory priming and activation sequence promote autologous tissue injury. J. Trauma 30, S44-S49 (1990).
  4. Aringer, M. and Smolen, J.S., SLE - Complex cytokine effects in a complex autoimmune disease: tumor necrosis factor in systemic lupus erythematosus. Arthritis Res. Ther. 5, 172-177 (2003).
  5. Ballara, S., Taylor, P.C., Reusch, P., Marme, D., Feldmann, M., Maini, R. N., and Paleolog, E.M., Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis. Arthritis Rheum. 44, 2055-2064 (2001). https://doi.org/10.1002/1529-0131(200109)44:9<2055::AID-ART355>3.0.CO;2-2
  6. Balomenos, D., Rumold, R., and Theofilopoulos, A.N., Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest. 101(2), 364-371 (1998). https://doi.org/10.1172/JCI750
  7. Barbarin, V., Xing, Z., Delos, M., Lison, D., and Huaux, F., Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles. Am. J. Physiol. Lung Cell Mol. Physiol. 288(5), L841- L848 (2005). https://doi.org/10.1152/ajplung.00329.2004
  8. Betz, M. and Fox, B.S., Prostaglandin $E_2$ inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146, 108-113 (1991).
  9. Chae, B.S., Bamboo Culm Extract attenuates early development of systemic inflammation in pristane-primed lupus mice. Natural Product Sciences 16(4), (2010) in press.
  10. Chae, B.S. and Park, B.H., Bamboo Culm Extract downregulated activation of NKT- and B- cells and production of IL-6 in pristaneinduced lupus mice. Natural Product Sciences 15(4), 222-228 (2009).
  11. Chae, B.S., Park, J.S., and Shin, T.Y., Endotoxin induces late increase in the production of pulmonary proinflammatory cytokines in murine lupus-like pristane-primed model. Arch. Pharm. Res. 29(4), 302-309 (2006). https://doi.org/10.1007/BF02968575
  12. Chae, B.S. and Shin, T.Y., Immunoregulatory abnormalities of T cells and hyperreactivity of B cells in the in vitro immune response in pristaneinduced lupus mice. Arch. Pharm. Res. 30(2), 191-198 (2007). https://doi.org/10.1007/BF02977694
  13. Chae, B.S., Shin, T.Y., Kim, D.K., Eun, J.S., Leem, J.Y., and Yang, J.H., Prostaglandin $E_2$-mediated dysregulation of proinflammatory cytokine production in pristane-induced lupus mice. Arch. Pharm. Res. 31, 503- 510 (2008). https://doi.org/10.1007/s12272-001-1185-6
  14. Chowdhary, V.R., Grande, J.P., Luthra, H.S., and David, C.S., Characterization of haemorrhagic pulmonary capillaritis: another manifestation of Pristane-induced lupus. Rheumatology (Oxford) 46(9), 1405-1410 (2007). https://doi.org/10.1093/rheumatology/kem117
  15. Chun, H.Y., Chung, J.W., Kim, H.A., Yun, J.M., Jeon, J.Y., Ye, Y.M., Kim, S.H., Park, H.S., and Suh, C.H., Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J. Clin. Immunol. 27, 461-466 (2007). https://doi.org/10.1007/s10875-007-9104-0
  16. Ciprandi, G., Murdaca, G., Colombo, B.M., De Amici, M., and Marseglia, G.L., Serum vascular endothelial growth factor in allergic rhinitis and systemic lupus erythematosus. Hum. Immunol. 69, 510-512 (2008). https://doi.org/10.1016/j.humimm.2008.05.010
  17. Dean, G.S., Tirrell-Price, J., Crawley, E., and Isenberg, D.A., Cytokines and systemic lupus erythematosus. Ann. Rheum. Dis. 59, 243-251 (2000). https://doi.org/10.1136/ard.59.4.243
  18. Green, T.P., Johnson, D.E., Marchessault, R.P., and Gatto, C.W., Transvascular flux and tissue accrual of Evans blue: effects of endotoxin and histamine. J. Lab. Clin. Med. 111, 173-183 (1988).
  19. Groen, H., ter Borg, E.J., Postma, D.S., Wouda, A.A., van der Mark, T.W., and Kallenberg, C.G., Pulmonary function in systemic lupus erythematosus is related to distinct clinical, serologic, and nailfold capillary patterns. Am. J. Med. 93(6), 619-627 (1992). https://doi.org/10.1016/0002-9343(92)90194-G
  20. Haas, C., Ryffel, B., and Le Hir, M., IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupusprone (NZB x NZW)F1 mice. J. Immunol. 160, 3713-3718 (1998).
  21. Haupt, H.M., Moore, G.W., and Hutchins, G.M., The lung in systemic lupus erythematosus. Analysis of the pathologic changes in 120 patients. Am. J. Med. 71(5), 791-798 (1981). https://doi.org/10.1016/0002-9343(81)90366-1
  22. Herrera-Acosta, J., Reyes, P.A., Lopez Manay, G., Padilla, L., Cerdas Calderon, M., Ruiz, A., and Perez Grovas, H., Inhibition of prostaglandin synthesis results in suppression of renal functional reserve in lupus nephritis. Rev. Invest. Clin. 39, 107-114 (1987).
  23. Hinson, R.M., Williams, J.A., and Shacter, E., Elevated interleukin 6 is induced by prostaglandin $E_2$ in a murine model of inflammation: possible role of cyclooxygenase-2. Proc. Natl. Acad. Sci. U S A 93, 4885-4890 (1996). https://doi.org/10.1073/pnas.93.10.4885
  24. Hoffman, R.W., T cells in the pathogenesis of systemic lupus erythematosus. Clin. Immunol. 113, 4-13 (2004). https://doi.org/10.1016/j.clim.2004.05.001
  25. Karim, M.Y., Miranda, L.C., Tench, C.M., Gordon, P.A., D'cruz, D.P., Khamashta, M.A., and Hughes, G.R., Presentation and prognosis of the shrinking lung syndrome in systemic lupus erythematosus. Semin. Arthritis Rheum. 31(5), 289-298 (2002). https://doi.org/10.1053/sarh.2002.32555
  26. Keane, M.P. and Lynch, J.P. III. Pleuropulmonary manifestations of systemic lupus erythematosus. Thorax. 55(2), 159-166 (2000). https://doi.org/10.1136/thorax.55.2.159
  27. Ishihara, K. and Hirano, T., IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 13, 357-368 (2002). https://doi.org/10.1016/S1359-6101(02)00027-8
  28. Ito, Y., Akao, Y., Shimazawa, M., Seki, N., Nozawa, Y., and Hara, H., Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity. CNS Drug Rev. 13, 296-307 (2007). https://doi.org/10.1111/j.1527-3458.2007.00017.x
  29. Lee, M.J., Park, W.H., Song, Y.S., Lee, Y.W., Song, Y.O., and Moon, G.S., Effect of bamboo culm extract on oxidative stress and genetic expression: bamboo culm extract ameliorates cell adhesion molecule expression and NFkappaB activity through suppression of the oxidative stress. Clin Nutr. 27(5), 755-763 (2008). https://doi.org/10.1016/j.clnu.2008.06.002
  30. Liang, B., Gardner, D.B., Griswold, D.E., Bugelski, P.J., and Song, X.Y., Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus. Immunology 119(3), 296-305 (2006). https://doi.org/10.1111/j.1365-2567.2006.02433.x
  31. Llorente, L., Zou, W., Levy, Y., Richaud-Patin, J., Wijdenes, J., Alcocer- Varela, J., Morel-Fourrier, B., Brouet, J.C., Alarcon-Segovia, D., Galanaud, P., and Emilie, D., Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J. Exp. Med. 181, 839-844 (1995). https://doi.org/10.1084/jem.181.3.839
  32. Nagy, G., Koncz, A., and Perl, A., T- and B-cell abnormalities in systemic lupus erythematosus. Crit. Rev. Immunol. 25(2), 123-140 (2005). https://doi.org/10.1615/CritRevImmunol.v25.i2.30
  33. Nakahara, H., Song, J., Sugimoto, M., Hagihara, K., Kishimoto, T., Yoshizaki, K., and Nishimoto, N., Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum. 48, 1521-1529 (2003). https://doi.org/10.1002/art.11143
  34. Satoh, M., Kumar, A., Kanwar, Y.S., and Reeves, W.H., Anti-nuclear antibody production and immune-complex glomerulonephritis in BALB/c mice treated with pristane. Proc. Natl. Acad. Sci. U S A. 92(24), 10934-10938 (1995). https://doi.org/10.1073/pnas.92.24.10934
  35. Satoh, M. and Reeves, W.H., Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane. J. Exp. Med. 180(6), 2341-2346 (1994). https://doi.org/10.1084/jem.180.6.2341
  36. Seki, T., Kida, K., and Maeda, H., Immunostimulation-Mediated Antitumor Activity of Bamboo (Sasa senanensis) Leaf Extracts Obtained Under 'Vigorous' Condition. eCAM 7, 1-11 (2008).
  37. Tanita, T., Song, C., Kubo, H., Ono, S., Sagawa, M., Sato, M., Matsumura, Y., Kondo, T. and Fujimura, S., Stimulated neutrophils evoke signal transduction to increase vascular permeability in rat lungs. Tohoku J. Exp. Med. 189(3), 213-225 (1999). https://doi.org/10.1620/tjem.189.213
  38. Theofilopoulos, A.N., Koundouris, S., Kono, D.H., and Lawson, B.R., The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity. Arthritis Res. 3, 136-141 (2001). https://doi.org/10.1186/ar290
  39. Theofilopoulos, A.N. and Lawson, B.R., Tumour necrosis factor and other cytokines in murine lupus. Ann. Rheum. Dis. 58(Suppl 1), I49- 55 (1999). https://doi.org/10.1136/ard.58.2008.i49
  40. Tsai, C.Y., Wu, T.H., Tsai, S.T., Chen, K.H., Thajeb, P., Lin, W.M., Yu, H.S., and Yu, C.L., Cerebrospinal fluid interleukin-6, prostaglandin $E_2$ and autoantibodies in patients with neuropsychiatric systemic lupus erythematosus and central nervous system infections. Scand. J. Rheumatol. 23(2), 57-63 (1994). https://doi.org/10.3109/03009749409103028
  41. Ucker, D.S., Ashwell, J.D., and Nickas, G., Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation. J. Immunol. 143(11), 3461-9 (1989).
  42. Zhang, Y., Yao, X., Bao, B., and Zhang, Y., Anti-fatigue activity of a triterpenoid-rich extract from Chinese bamboo shavings (Caulis bamfusae in taeniam). Phytother. Res. 20, 872-876 (2006). https://doi.org/10.1002/ptr.1965