Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Protein Tyrosine Phosphatase 1B Inhibitory Activity from Some Vietnamese Medicinal Plants

  • Hoang, Duc Manh (Research Institute of Obesity Science, and Dept. of Food and Nutrition, Sungshin Women's University) ;
  • Trung, Trinh Nam (College of Pharmacy, Chungnam National University) ;
  • Hien, Phan Thi Thu (Traditional Medicinal Departments, Ministry of Health) ;
  • Ha, Do Thi (College of Pharmacy, Chungnam National University) ;
  • Van Luong, Hoang (Vietnam Military Medical University) ;
  • Lee, Myoung-Sook (Research Institute of Obesity Science, and Dept. of Food and Nutrition, Sungshin Women's University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
  • Received : 2010.09.06
  • Accepted : 2010.10.28
  • Published : 2010.12.31
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Abstract

Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signaling, has served as a potential drug target for the treatment of type 2 diabetes. The MeOH extracts of twenty-nine medicinal plants, traditionally used in Vietnam as anti-diabetes agents, were investigated for PTP1B inhibitory activity in vitro. The results indicated that, most materials showed moderate to strong inhibitory activity with $IC_{50}$ values ranging from $3.4\;{\mu}g/mL$ to $35.1\;{\mu}g/mL$; meanwhile, eleven extracts (37.9%) could demonstrate PTP1B activity with $IC_{50}$ values less than $15.5\;{\mu}g/mL$; sixteen extracts (55.2%) could demonstrate PTP1B activity with $IC_{50}$ values ranging from $15.5\;{\mu}g/mL$ to $35.1\;{\mu}g/mL$. The study may provide a proof, at least in a part, for the ethno-medical use in diabetes disease of these plants.

Keywords

References

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