Need for Development of Oriental Medicine-derived Systemic Treatments against Chronic Fatigue-associated Symptoms

만성피로의 체계화된 한의학적 치료법 연구의 필요성

  • Cho, Jung-Hyo (Internal Department of Oriental Medicine College, Daejeon University) ;
  • Son, Chang-Gue (Internal Department of Oriental Medicine College, Daejeon University)
  • 조정효 (대전대학교 한의과대학 간장면역학교실) ;
  • 손창규 (대전대학교 한의과대학 간장면역학교실)
  • Published : 2009.07.31

Abstract

Objectives: Fatigue is a prevalent symptom encompassing both acute and chronic manifestations. Most fatigue symptoms can be cured by taking a rest or removing underlying causes. However, chronic fatigue is frequently problematic due to its duration and effect on quality of life. There are no particularly effective therapies for chronic fatigue of unknown causes, and patients in Korea usually visit an Oriental clinic. This study aimed to analyze the current status of treatments and patients with chronic fatigue, and then map out of a strategy for development of generalized-treatments for chronic fatigue in Oriental Medicine. Methods: Clinical information related to chronic fatigue was selected from various different databases such as PubMed, KoreaMed, KStudy, DBPIA, OIM, and KOMS. Also, to understand current tendency of medical examination and treatment related with chronic fatigue, we requested Health Insurance Review & Assessment Service for clinical datum from 2003 to 2007. Results: The medical fees of National Health Insurance related with fatigue show an explosive year-on-year increase. On the other hand, it has been decreasing annually in the western medical fields. To take charge of clinical fields related with chronic fatigue by Oriental Medicine, we should make a unified diagnostic system. Then, we should also make standard evaluation tools and develop herbal drugs according to this unified diagnostic system. Conclusions: Fatigue-related symptoms will be a main target of Oriental medicine in the future. We expect that various studies related with chronic fatigue will be undertaken hereafter.

Keywords

References

  1. Jorgensen R. Chronic fatigue: an evolutionary concept analysis. J Adv Nurs. 2008;63(2):199-207. https://doi.org/10.1111/j.1365-2648.2008.04649.x
  2. Wessely S, Chalder T, Hirsch S, Wallace P, Wright D. The prevalence and morbidity of chronic fatigue and chronic fatigue syndrome: a prospective primary care study. American Journal of Public Health. 1997;87(9):1449-55. https://doi.org/10.2105/AJPH.87.9.1449
  3. Ricci JA, Chee E, Lorandeau AL, Berger J. Fatigue in the US workforce: prevalence and implications for lost productive work time. Journal of Occupational and Environmental Medicine. 2007;49(1):1-10. https://doi.org/10.1097/01.jom.0000249782.60321.2a
  4. Shin HC, Choi HC, Song SW, Choi HS. Patients with fatigue in family practice . J Korean Acad Fam Med. 1993;14(12):833-42.
  5. Available from URL: http://www.asiailbo.co.kr/plan/-fn=v&no=9503&cid =31040500& pg=1
  6. Sekiya N, Shimada Y, Shintani T, Tahara E, Kouta K, Shibahara N, et al. Reduction of perception of chronic fatigue in an observational study of patients receiving 12 weeks of Kampo therapy. Journal of Alternative and Complementary. Medicine. 2005;11(5):895-901. https://doi.org/10.1089/acm.2005.11.895
  7. Glacken M, Coates V, Kernohan G, Hegarty J. The experience of fatigue for people living with hepatitis C. Journal of Clinical Nursing. 2003;12(2):244-52. https://doi.org/10.1046/j.1365-2702.2003.00709.x
  8. Jones DE, Bhala N, Burt J, Goldblatt J, Prince M, Newton JL. Four-year follow up of fatigue in a geographically defined primary biliary cirrhosis patient cohort. Gut. 2006;55(4):536-541. https://doi.org/10.1136/gut.2005.080317
  9. Kralik D, Telford K, Price K, Koch T. Women's experiences of fatigue in chronic illness. Journal of Advanced Nursing. 2005;52(4):372-80. https://doi.org/10.1111/j.1365-2648.2005.03602.x
  10. Kim CH, Shin HC. Clinic for chronic fatigue. J Korean Acad Fam Med. 1998;19(8):592-603.
  11. Yoo SR, Son CG. Survey Analysis of 101 Subjects Using Herbal Medicine with Deer Antler. J Korean Oriental Med. 2008;29(2):41-6.
  12. Kim SH, Lee JH, Lee SB, Choi MY, Kim YC, Woo HJ. Speculation of the Correlationship between Public Health Practice, Consumption and Fatigue in Patients who Complain Fatigue. Korean J. Orient. Int. Med. 2008:29(1)219-30.
  13. Sharpe M, Wilks D. Fatigue. BMJ. 2002;325(7362):480-3. https://doi.org/10.1136/bmj.325.7362.480
  14. Clarke JN, James S. The radicalized self: the impact on the self of the contested nature of the diagnosis of chronic fatigue syndrome. Social Science & Medicine. 2003;57:1387-95. https://doi.org/10.1016/S0277-9536(02)00515-4
  15. Holmes GP, Kaplan JE, Gantz NM, Komaroff AL, Schonberger LB, Straus SE, et al. Chronic fatigue syndrome: a working case definition. Ann Intern Med. 1988;108:387-9. https://doi.org/10.7326/0003-4819-108-3-387
  16. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. International chronic fatigue syndrome study group. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994;121: 953-9. https://doi.org/10.7326/0003-4819-121-12-199412150-00009
  17. Hickie I, Kirk K, Martin N. Unique genetic and environmental determinants of prolonged fatigue: a twin study. Psychol Med. 1999;29(2):259-68. https://doi.org/10.1017/S0033291798007934
  18. Klimas NG, Salvato FR, Morgan R, Fletcher MA. Immunologic abnormalities in chronic fatigue syndrome. J Clin Microbiol. 1990;28(6):1403-10.
  19. Staines DR. Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis. Clin Dev Immunol. 2006;13(1):25-39. https://doi.org/10.1080/17402520600568252
  20. Visser MRM, Smets EMA. Fatigue, depression and quality of life in cancer patients: how are they related- Supportive Care in Cancer. 1998;6:101-8. https://doi.org/10.1007/s005200050142
  21. Kato K, Sullivan PF, Evengard B, Pedersen NL. Premorbid predictors of chronic fatigue. Archives of General Psychiatry. 2006;63:1267-72. https://doi.org/10.1001/archpsyc.63.11.1267
  22. Yi JH, Lee JH, Park SM, Kim YC, Lee JH, Woo HJ. Clinical investigation and follow-up monitering of fatigue patients visiting the Oriental medical hospital. J. Korean Oriental Med. 2002;21(4):55-63.
  23. Oh TH, Jung SG, Rhee HK. Review of literature on languor and fatigue. Korean J Orient Int Med. 1990;11(2):80-92.
  24. Jeon SB, Oh TH, Jung SG, Rhee HK. Review of literature on languor and fatigue. Korean J Orient Int Med. 1991;12(1)31-44.
  25. Lloyd AR, Hickie I, Boughton CR, Spencer O, Wakefield D. Prevalence of chronic fatigue syndrome in an Australian population. Med J Aust. 1990;153: 522-8.
  26. Bates D, Schmitt W, Buchwald D, Ware NC, Lee J, Thoyer E, et al. Prevalence of fatigue and chronic fatigue syndrome in a primary care practice. Arch Intern Med. 1993;153:2759-65. https://doi.org/10.1001/archinte.153.24.2759
  27. Kroenke K, Wood DR, Mangelsdorff AD, Meier NJ, Powell JB. Chronic fatigue in primary care; prevalence, patient characteristics, and outcome. JAMA. 1988; 260: 929-34. https://doi.org/10.1001/jama.260.7.929
  28. Hickie IB, Hooker AW, Hadzi-Pavlovic D, Bennett BK, Wilson AJ, Lloyd AR. Fatigue in selected primary care settings: sociodemographic and psychiatric correlates. Med J Aust 1996;164 :585-8.
  29. Jason LA, Richman JA, Rademaker AW, Jordan KM, Plioplys AV, Taylor RR, et al. A communitybased study of chronic fatigue syndrome. Arch Intern Med. 1999;159(18):2129-37. https://doi.org/10.1001/archinte.159.18.2129
  30. Oh MK. Evaluation of the chronic fatigue of periodic health examination visitors. J Korean Acad Fam Med. 1990;11(4):12-9.
  31. Kim YB, Kim BW. A statistical study on the causative factors of chronic fatigue among workers. Chonnam medical journal. 1996;23(4)605-17.
  32. Ji JD, Choi SJ, Lee YH, Song GG. Incidence and clinical manifestations of chronic fatigue in Korea. KJIM. 1999;56(6):738-44.
  33. Youn BB, Lee KS, Kang HC, Shin KK. An analysis of fatigue among outpatients. J Korean Acad Fam Med. 1999;20: 978-87.
  34. Kim CH, Shin HC, Park YW. The prevalence of chronic fatigue and CFS-a hospital based study. J Korean Acad Fam Med. 2000;21: 1288-98.
  35. Kim CH, Shin HC, Won CW. Prevalence of chronic fatigue and chronic fatigue syndrome in Korea: community-based primary care study. J Korean Med Sci. 2005 Aug;20(4):529-34. https://doi.org/10.3346/jkms.2005.20.4.529
  36. Kim SG, Lee YJ, Oh MK, Youn BB. Evaluation of chronic fatigue of periodic health examination. J Korean Acad Fam Med. 1990;11(12):34-9.
  37. Kim CH, Shin HC. Clinical characterization of chronic fatigue and chronic fatigue syndrome in Korea. J Korean Acad Fam Med. 1998;19(12):1354-67.
  38. Cho JH, Yoo SR, Cho JK, Son CG. Analytic Study for Syndrome-differentiation and Sasangconstitution in 72 Adults with Chronic Fatigue. J Korean Oriental Med. 2007;28(4):791-6.
  39. Lee DE. The effect of Dangguibohyultang and Ssanbohwan on the muscle-fatigue recovery in rats. J Korean Oriental Med. 1996;17(1): 361-72.
  40. Kim SW, Du HK. Experimental study on the effects of Palmiwon. Korean J. Orient. Int. Med. 1989:10(1):81-91.
  41. Na CS, Youn DH, Choi DH, Kim JS, Jang KS. The effect of Bambusaw caulis in liquamen. J Korean Oriental Med. 2001;22(4): 90-100.