Journal of Animal Science and Technology

Korean Society of Animal Sciences and Technology (한국축산학회)
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Physiological Effects of Diethylstilbestrol Exposure on the Development of the Chicken Oviduct

  • Seo, Hee-Won (WCU Biomodulation Major, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Park, Kyung-Je (WCU Biomodulation Major, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Lee, Hyung-Chul (WCU Biomodulation Major, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Kim, Dae-Yong (Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Song, Yong-Sang (WCU Biomodulation Major, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Lim, Jeong-Mook (WCU Biomodulation Major, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Song, Gwon-Hwa (WCU Biomodulation Major, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) ;
  • Han, Jae-Yong (WCU Biomodulation Major, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University)
  • Received : 2009.10.13
  • Accepted : 2009.12.01
  • Published : 2009.12.01
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Abstract

Estrogen has dramatic effects on the development and function of the reproductive tract in mammals. Although diethylstilbestrol (DES) triggers the development of reproductive organs in immature animals, continued exposure to DES induces dysfunction of the female reproductive tract in mice. To investigate the effects of neonatal estrogen exposure on the reproductive tract of female chickens, we implanted DES pellets into the abdominal region of immature female chicks and then examined the effects of DES on the oviducts of both immature chicks and sexually mature chickens (30 weeks old). DES induced mass growth and differentiation of the oviduct in immature chicks. The chick oviduct increased by 2.7- and 29-fold in length and weight, respectively, following primary DES stimulation. In secondary DES stimulation, the length and weight of the chick oviduct increased by 4.5- and 74-fold, respectively. Additionally, DES treatments caused abnormal development of the infundibulum and magnum in hen oviducts. Furthermore, infundibulum abnormality gave rise to unusual ovulation of follicles and resulted in infertility and dysfunction of the magnum, such as less production of egg white proteins. Our results indicate that DES exposure during early developmental stages in chickens has detrimental effects on the development and maintenance of the female reproductive tract after sexual maturation.

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References

  1. Couse, J. F. and Korach, K. S. 2004. Estrogen receptor-alpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology. 205(1-2):55-63. https://doi.org/10.1016/j.tox.2004.06.046
  2. De Pol, A., Benelli, A., Arletti, R., Cavazzuti, E., Sena, P., Vaccina, F. and Marzona, L. 2001. Influence of estrogens and oxytocin on germ cells death in the neonatal mammalian ovary. Ital J Anat Embryol. 106 (2 Suppl 2):233-239.
  3. Dougherty, D. C. and Sanders, M. M. 2005. Estrogen action: revitalization of the chick oviduct model. Trends Endocrinol Metab. 16(9):414-419. https://doi.org/10.1016/j.tem.2005.09.001
  4. Gasc, J. M. 1980. Estrogen target cells in gonads of the chicken embryo during sexual differentiation. J Embryol Exp Morphol. 55:331-342.
  5. Hewitt, S. C., Harrell, J. C. and Korach, K. S. 2005. Lessons in estrogen biology from knockout and transgenic animals. Annu Rev Physiol. 67:285-308. https://doi.org/10.1146/annurev.physiol.67.040403.115914
  6. Huang, W. W., Yin, Y., Bi, Q., Chiang, T. C., Garner, N., Vuoristo, J., McLachlan, J. A. and Ma, L. 2005. Developmental diethylstilbestrol exposure alters genetic pathways of uterine cytodifferentiation. Mol Endocrinol. 19(3):669-682. https://doi.org/10.1210/me.2004-0155
  7. Jefferson, W., Newbold, R., Padilla-Banks, E. and Pepling, M. 2006. Neonatal genistein treatment alters ovarian differentiation in the mouse: inhibition of oocyte nest breakdown and increased oocyte survival. Biol Reprod. 74(1):161-168. https://doi.org/10.1095/biolreprod.105.045724
  8. Kim, S. Y. 2006. Gene manipulation for chicken oviduct epthelial cells by lentivirus vector. A thesis for the degree of master of science, Seoul national university.
  9. Kohler, P. O., Grimley, P. M., O'Malley, B. W. 1968. Protein synthesis: differential stimulation of cell-specific proteins in epithelial cells of chick oviduct. Science. 160(823):86-87. https://doi.org/10.1126/science.160.3823.86
  10. Kohler, P. O., Grimley, P. M. and O'Malley, B. W. 1969. Estrogen-induced cytodifferentiation of the ovalbumin-secreting glands of the chick oviduct. J Cell Biol. 40(1):8-27. https://doi.org/10.1083/jcb.40.1.8
  11. Lague, P. C., van Tienhoven, A., Cunningham, F. J. 1975. Concentrations of estrogens, progesterone and LH during the ovulatory cycle of the laying chicken [Gallus domesticus]. Biol Reprod. 12(5):590-598. https://doi.org/10.1095/biolreprod12.5.590
  12. Lee, S. I., Lee, W. K., Shin, J. H., Han, B. K., Moon, S., Cho, S., Park, T., Kim, H. and Han, J. Y. 2009. Sexually dimorphic gene expression in the chick brain before gonadal differentiation. Poult Sci. 88(5):1003-1015. https://doi.org/10.3382/ps.2008-00197
  13. McKnight, G. S. 1978. The induction of ovalbumin and conalbumin mRNA by estrogen and progesterone in chick oviduct explant cultures. Cell. 14(2):403-413. https://doi.org/10.1016/0092-8674(78)90125-3
  14. McNatty, K. P., Makris, A., DeGrazia, C., Osathanondh, R. and Ryan, K. J. 1979. The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro. J Clin Endocrinol Metab. 49(5):687-699. https://doi.org/10.1210/jcem-49-5-687
  15. Monroe, D. G., Berger, R. R., Sanders, M. M. 2002. Tissueprotective effects of estrogen involve regulation of caspase gene expression. Mol Endocrinol. 16(6):1322-1331. https://doi.org/10.1210/me.16.6.1322
  16. Monroe, D. G., Jin, D. F., Sanders, M. M. 2000. Estrogen opposes the apoptotic effects of bone morphogenetic protein 7 on tissue remodeling. Mol Cell Biol. 20(13):4626-4634. https://doi.org/10.1128/MCB.20.13.4626-4634.2000
  17. Newbold, R. R. 2004. Lessons learned from perinatal exposure to diethylstilbestrol. Toxicol Appl Pharmacol. 199(2):142-150. https://doi.org/10.1016/j.taap.2003.11.033
  18. O'Malley, B. W. 1969. Hormonal regulation of nucleic acid and protein synthesis. Trans N Y Acad Sci. 31(5):478-503. https://doi.org/10.1111/j.2164-0947.1969.tb02930.x
  19. Oka, T., Schimke, R. T. 1969. Interaction of estrogen and progesterone in chick oviduct development. II. Effects of estrogen and progesterone on tubular gland cell function. J Cell Biol. 43(1):123-137. https://doi.org/10.1083/jcb.43.1.123
  20. Palmiter, R. D. and Wrenn, J. T. 1971. Interaction of estrogen and progesterone in chick oviduct development. 3. Tubular gland cell cytodifferentiation. J Cell Biol. 50(3):598-615. https://doi.org/10.1083/jcb.50.3.598
  21. Rodriguez-Maldonado, E., Velazquez, P. N., Juarez-Oropeza, M. A. and Pedernera, E. 1996. Steroid metabolism in theca externa cells from preovulatory follicles of domestic hen (Gallus domesticus). Gen Comp Endocrinol. 101(2):173-179. https://doi.org/10.1006/gcen.1996.0019
  22. Teng, C. S. and Teng, C. T. 1985. Decreased ovalbumin-gene response to oestrogen in the prenatally diethylstilboestrolexposed chick oviduct. Biochem J. 228(3):689-695. https://doi.org/10.1042/bj2280689
  23. Voronina, E., Lovasco, L. A., Gyuris, A., Baumgartner, R. A., Parlow, A. F. and Freiman, R. N. 2007. Ovarian granulosa cell survival and proliferation requires the gonad.selective TFIID subunit TAF4b. Dev Biol. 303(2):715-726. https://doi.org/10.1016/j.ydbio.2006.12.011

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