Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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신종 H1N1 인플루엔자

Novel swine-origin H1N1 influenza

  • 이진아 (서울대학교 의과대학 소아과학교실) ;
  • 이환종 (서울대학교 의과대학 소아과학교실)
  • Lee, Jina (Department of Pediatrics, Seoul National University Children's Hospital) ;
  • Lee, Hoan Jong (Department of Pediatrics, Seoul National University Children's Hospital)
  • 투고 : 2009.07.28
  • 심사 : 2009.07.30
  • 발행 : 2009.08.15
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초록

Since its identification in April 2009, a swine-origin H1N1 influenza A virus (S-OIV) which is a reassortment of gene segments from both North American triple-reassortant and Eurasian swine influenza has been widely spread among humans in unexpected rapidity. To date, each gene segment of the 2009 influenza A (H1N1) outbreak viruses have shown high (99.9%) neucleotide sequence identity. As of July 6, 94,512 people have been infected in 122 countries, of whom 429 have died with an overall case-fatality rate of <0.5%. Most confirmed cases of S-OIV infection have been characterized by self-limited, uncomplicated febrile respiratory illness and 38% of cases have also included vomiting or diarrhea. Standard plus droplet precautions should be adhered to at all times. Tests on S-OIV have indicated that current new H1N1 viruses are sensitive to neuraminidase inhibitors (oseltamivir). However, current less virulent S-OIV may evolve into a pathogenic strain or acquire antiviral resistance, potentially with more severe clinical consequences. Efforts to control these outbreaks would be based on our understanding of novel S-OIV and previous influenza pandemics.

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참고문헌

  1. World Health Organization [homepage on the Internet]. Geneva, Switzerland: WHO c2009 [updated 2009 June 11 cited 2009 July 17]. Global Alert and Response; [about 2 screens]. Available from: URL: http://www.who.int/csr/diseeas/swineflu/frequently_asked_questions/levels_pandemic_alert/en/index.html
  2. Katz J, Hancock K, Veguilla V, Zhong W, Lu XH, Sun H, et al. Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR Morb Mortal Wkly Rep 2009;58: 521-4
  3. World Health Organization [homepage on the Internet]. Geneva, Switzerland: WHO c2009 [updated 2009 July 6 cited 2009 July 10]. Global Alert and Response; [about 2 screens]. Available from: URL: http://www.who.int/csr/don/2009_07_ 06/en/index.html
  4. Neumann G, Noda T, Kawaoka Y. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 2009; 459:931-9 https://doi.org/10.1038/nature08157
  5. Brownstein JS, Freifeld CC, Madoff LC. Influenza A (H1N1) virus, 2009--online monitoring. N Engl J Med 2009;360:2156 https://doi.org/10.1056/NEJMp0904012
  6. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009;360:2605-15 https://doi.org/10.1056/NEJMoa0903810
  7. Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, et al. Antigenic and genetic characteristics of swine-origin 2009 A (H1N1) influenza viruses circulating in humans. Science 2009;325:197-201 https://doi.org/10.1126/science.1176225
  8. Munster VJ, de Wit E, van den Brand JM, Herfst S, Schrauwen EJ, Bestebroer TM, et al. Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets. Science 2009;325:481-3
  9. Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, Hernandez M, Quiones-Falconi F, Bautista E, et al. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med. In press 2009
  10. Hageman JC, Uyeki TM, Francis JS, Jernigan DB, Wheeler JG, Bridges CB, et al. Severe community-acquired pneumoniadue to Staphylococcus aureus, 2003-04 influenza season. Emerg Infect Dis 2006;12:894-9
  11. McCullers JA. Insights into the interaction between influenza virus and pneumococcus. Clin Microbiol Rev 2006;19:571-82 https://doi.org/10.1128/CMR.00058-05
  12. O'Brien KL, Walters MI, Sellman J, Quinlisk P, Regnery H, Schwartz B, et al. Severe pneumococcal pneumonia in previously healthy children: the role of preceding influenza infection. Clin Infect Dis 2000;30:784-9 https://doi.org/10.1086/313772
  13. Maines TR, Jayaraman A, Belser JA, Wadford DA, Pappas C, Zeng H, et al. Transmission and pathogenesis of swine- origin 2009 A (H1N1) influenza viruses in ferrets and mice. Science 2009;325:484-7 https://doi.org/10.1126/science.1177238
  14. Cate TR, Kasel JA, Couch RB, Six HR, Knight V. Clinical trials of bivalent influenza A/New Jersey/76-A/Victoria/75 vaccines in the elderly. J Infect Dis 1977;136 Suppl:S518-25 https://doi.org/10.1093/infdis/136.Supplement_3.S518
  15. Dolin R, Wise TG, Mazur MH, Tuazon CU and Ennis FA. Immunogenicity and reactogenicity of influenza A/New Jersey/76 virus vaccines in normal adults. J Infect Dis 1977; 136 Suppl:S435-42 https://doi.org/10.1093/infdis/136.Supplement_3.S435
  16. World Health Organization [homepage on the Internet]. Geneva, Switzerland: WHO c2009 [updated 2009 July 13 cited 2009 July 17]. Global Alert and Response; [about 2 screens]. Available from: URL: http://www.who.int/csr/disease/swineflu/notes/h1n1_vaccine_20090713/en/index.html
  17. World Health Organization [homepage on the Internet]. Geneva, Switzerland: WHO c2009 [updated 2009 July 16 cited 2009 July 20]. Global Alert and Response; [about 2 screens]. Available from: URL: http://www.who.int/csr/disease/swineflu/notes/h1n1_surveillance_20090710/en/index.html
  18. World Health Organization Regional Office for Europe [homepage on the Internet]. Geneva, Switzerland: WHO c2009 [updated 2009 April 30; cited 2009 July 18]. CDC protocol of realtime RT-PCR for influenza A (H1N1) [9screens]. Available from: URL: http://www.euro.who.int/Document/INF/CDC_realtime_RT PCR_H1N1.pdf
  19. Faix DJ, Sherman SS and Waterman SH. Rapid-test sensitivity for novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med. In press 2009
  20. Carrat F, Vergu E, Ferguson NM, Lemaitre M, Cauchemez S, Leach S, et al. Time lines of infection and disease in human influenza: a review of volunteer challenge studies. Am J Epidemiol 2008;167:775-85 https://doi.org/10.1093/aje/kwm375
  21. Blachere FM, Lindsley WG, Pearce TA, Anderson SE, Fisher M, Khakoo R, et al. Measurement of airborne influenza virus in a hospital emergency department. Clin Infect Dis 2009;48: 438-40 https://doi.org/10.1086/596478
  22. World Health Organization [homepage on the Internet]. Geneva, Switzerland: WHO c2009 [updated 2009 May 13 cited 2009 July 15]. Global Alert and Response; [3 screens]. Available from: URL: http://www.who.int/csr/resources/publications/swineflu/M2_DetailedPyrosequencing_20090513.pdf
  23. World Health Organization [homepage on the Internet]. Geneva, Switzerland: WHO c2009 [updated 2009 May 13 cited 2009 July 15]. Global Alert and Response; [3 screens]. Available from: URL: http://www.who.int/csr/resources/publications/swineflu/NA_DetailedPyrosequencing_20090513.pdf
  24. Update: Infections With a Swine-Origin Influenza A (H1N1) Virus --- United States and Other Countries, April 28, 2009. MMWR Morb Mortal Wkly Rep 200958:431-3. (Also available from: URL: http://www.cdc.gov/mmwr/preview/mmwrhtml/ mm5816a5.htm)
  25. Centers for Disease Control and Prevention [homepage on the Internet]. Atlanta, GA: CDC c2009 [updated 2009 July 14 cited 2009 July 16]. Emergency Use Authorization (EUA) of Medical Products and Devices [3 screens]. Available from: URL: http://www.cdc.gov/h1n1flu/eua/pdf/tamiflu-hcp.pdf
  26. World Health Organization [homepage on the Internet]. Geneva, Switzerland: WHO c2009 [updated 2009 May 21; cited 2009 July 17]. Global Alert and Response; [6 screens]. Available from: URL: http://www.who.int/csr/resources/publications/swineflu/clinical_managementH1N1_21_May_2009.pdf
  27. World Health Organization [homepage on the Internet]. Geneva, Switzerland: WHO c2009 [updated 2009 March 18 cited 2009 July 10]. Global Alert and Response; [4 screens]. Available from: URL: http://www.who.int/csr/disease/influenza/ H1N1 webupdate2009031820ed_ns.pdf
  28. Ukmedix [homepage on the Internet]. London, UK: Ukmedix, Inc.; c2009 [updated 2009 July 1 cited 2009 July 24]. Tamiflu Resistance Case Confirmed [about 1 screen]. Available from: URL: http://www.ukmedix.com/tamiflu/tamiflu_resista nce_case_confirmed4784.cfm
  29. European Centre for Disease Prevention and Control [homepage on the Internet]. Stockholm, Sweden: EU c2009 [updated 2009 July 9 cited 2009 July 24]. ECDC Threat Assessment [4 screens]. Available from: URL:http://www.ecdc. europa.eu/en/files/pdf/Health_topics/TA_Swine_influenza_Canada-90709.pdf
  30. Hong Kong Special Administrative Region (HKSAR) Government [homepage on the Internet]. Hong Kong: Government; c2009 [updated 2009 July 3 cited 2009 July 24]. Press Releases [about 1 screen]. Available from: URL: http://www.info.gov.hk/gia/general/200907/03/P200907030213.htm
  31. Belshe RB. Implications of the emergence of a novel H1 influenza virus. N Engl J Med 2009;360:2667-8 https://doi.org/10.1056/NEJMe0903995
  32. Treanor JJ, Campbell JD, Zangwill KM, Rowe T, Wolff M. Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine. N Engl J Med 2006;354:1343-51 https://doi.org/10.1056/NEJMoa055778
  33. Bernstein DI, Edwards KM, Dekker CL, Belshe R, Talbot HK, Graham IL, et al. Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults. J Infect Dis 2008;197:667-75 https://doi.org/10.1086/527489
  34. Stephenson I, Nicholson KG, Hoschler K, Zambon MC, Hancock K, DeVos J, et al. Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1. N Engl J Med 2008;359:1631-3 https://doi.org/10.1056/NEJMc0805274
  35. Morens DM, Taubenberger JK, Fauci AS. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis 2008;198:962-70 https://doi.org/10.1086/591708
  36. Morens DM, Taubenberger JK, Fauci AS. The persistent legacy of the 1918 influenza virus. N Engl J Med 2009;361: 225-9 https://doi.org/10.1056/NEJMp0904819
  37. Brundage JF, Shanks GD. What really happened during the 1918 influenza pandemic? The importance of bacterial secondary infections. J Infect Dis 2007;196:1717-8; author reply 1718-9 https://doi.org/10.1086/522355
  38. Bartlett JG. Planning for avian influenza. Ann Intern Med 2006;145:141-4
  39. Andreasen V, Viboud C, Simonsen L. Epidemiologic characterization of the 1918 influenza pandemic summer wave in Copenhagen: implications for pandemic control strategies. J Infect Dis 2008;197:270-8 https://doi.org/10.1086/524065
  40. Miller MA, Viboud C, Balinska M,Simonsen L. The signature features of influenza pandemics--implications for policy. N Engl J Med 2009;360:2595-8 https://doi.org/10.1056/NEJMp0903906

피인용 문헌

  1. H1N1 인플루엔자 바이러스 감염과 동반되어 발생한 신증후군 1례 vol.14, pp.2, 2009, https://doi.org/10.3339/jkspn.2010.14.2.218
  2. Comparison of Clinical Manifestation and Laboratory Findings between H1N1 and Influenza B Infection vol.22, pp.1, 2009, https://doi.org/10.7581/pard.2012.22.1.64