The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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A Comparative Study about Cerebrovascular Reactivity from a Single Medication and Continuous Medication on Healthy Subjects

우황청심원(牛黃淸心元)의 단독투여 및 연속투여에 따른 정상인의 뇌혈관반응도의 비교연구

  • Hwang, Jae-Woong (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Chang-Hyun (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Min, In-Kyu (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Young-Ji (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Leem, Jung-Tae (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Na, Byong-Jo (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Sung-Wook (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Jung-Mi (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Ko, Chang-Nam (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Bae, Hyung-Sup (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Jung, Woo-Sang (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Moon, Sang-Kwan (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Cho, Ki-Ho (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Yong-Suk (Department of Cardiovascular and Neurologic Diseases(StrokeCenter) College of Oriental Medicine, Kyung-Hee University)
  • 황재응 (경희대학교 한의과대학 심계내과학교실) ;
  • 김창현 (경희대학교 한의과대학 심계내과학교실) ;
  • 민인규 (경희대학교 한의과대학 심계내과학교실) ;
  • 김영지 (경희대학교 한의과대학 심계내과학교실) ;
  • 임정태 (경희대학교 한의과대학 심계내과학교실) ;
  • 나병조 (경희대학교 한의과대학 심계내과학교실) ;
  • 박성욱 (경희대학교 한의과대학 심계내과학교실) ;
  • 박정미 (경희대학교 한의과대학 심계내과학교실) ;
  • 고창남 (경희대학교 한의과대학 심계내과학교실) ;
  • 배형섭 (경희대학교 한의과대학 심계내과학교실) ;
  • 정우상 (경희대학교 한의과대학 심계내과학교실) ;
  • 문상관 (경희대학교 한의과대학 심계내과학교실) ;
  • 조기호 (경희대학교 한의과대학 심계내과학교실) ;
  • 김영석 (경희대학교 한의과대학 심계내과학교실)
  • Published : 2009.01.30
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Abstract

Objectives: Uwhangchungsim-won (DC) has been used in various medical fields such as stroke, hypertension, atherosclerosis, autonomic imbalance and mental instability, etc. The aim of this study was to evaluate the effect of UC on cerebral hemodynamics and estimate the appropriate dose of UC. Methods: We studied changes of hyperventilation-induced cerebrovascular reactivity and mean blood flow velocity of middle cerebral arteries (MCA) using transcranial Doppler. We observed the changes of mean blood pressure, pulse rate and expiratory CO2 using S/5 Compact Anesthesia Monitor from 10 healthy young volunteers who were administered UC twice a day in the 1 st section and then once a day in the 2nd section. Results: Mean blood pressure tended to decrease at 1 hour and pulse rate tended to decrease at 2 hours after second administration. After 2 hours, mean blood pressure rose to state before administration, but pulse rate maintained from 2 hours to 4 hours. The changes were not statistically significant. Cerebral blood flow velocity in middle cerebral artery was not statistically significant after second administration. Cerebrovascular reactivity increased from 2 hours to 4 hours after second administration. Conclusions: This study provides that administration of UC twice a day is more effective on hyperventilation-induced cerebrovascular reactivity than administration of UC once a day.

Keywords

References

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