Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Stereoselective Synthesis of Diverse α-Hydroxy-β-amino Acids and It's Application for Synthesis of Dipeptide Expecting as a Protease Inhibitor

  • Jang, Sang-Hun (Department of Chemistry and Research Institute of Life Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University) ;
  • Kim, Ju-Young (Department of Chemistry and Research Institute of Life Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University) ;
  • Kim, Min-Kyu (Department of Chemistry and Research Institute of Life Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University) ;
  • Han, Jeong-Woo (Department of Chemistry and Research Institute of Life Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University) ;
  • Park, Ki-Hun (Department of Agricultural Chemistry and Division of Applied Life Science, Gyeongsang National University) ;
  • Yoon, Yong-Jin (Department of Chemistry and Research Institute of Natural Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University) ;
  • Lee, Sang-Gyeong (Department of Chemistry and Research Institute of Life Science, Graduate School for Molecular Materials and Nanochemistry, Gyeongsang National University)
  • Published : 2009.01.20
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Abstract

Few $\alpha$-Hydroxy-$\beta$-amino acids were synthesized via various nucleophilic addition of the epoxide and followed by stereoselective nucleophilic substitution reaction and eliminative cleavage of the acetal selectively in diacetal compound. One of the synthesized $\alpha$-Hydroxy-$\beta$-amino acid reacted with L-leucine methylester to give corresponding dipeptide in good yields.

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References

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