Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Poly(benzyl ether) Dendrimers Containing Core Diversitiesby Click Chemistry

  • Lee, Jae-Wook (Department of Chemistry and ‡Department of Medical Bioscience, Dong-A University) ;
  • Kim, Byoung-Ki (Department of Chemistry, Dong-A University) ;
  • Han, Seung-Choul (Department of Medical Bioscience, Dong-A University) ;
  • Kim, Ji-Hyeon (Department of Chemical and Bio Engineering, Kyungwon University)
  • Published : 2009.01.20
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Abstract

General, fast, and efficient methods for the synthesis of Fréchet-type dendrimers having core diversities were elaborated. Two core building blocks, 4,4'-(3,5-bis(propargyloxy)benzyloxy)bisphenyl and N,N,N',N'-tetra(prop-2- ynyloxycarbonylethyl)-1,2-diaminoethane, were designed to serve as the alkyne functionalities for dendrimer growth via click reactions with the azide-dendrons. The synthetic strategy involved an 1,3-dipolar cycloaddition reaction between an alkyne and an azide- functionalized Fréchet-type dendrons in the presence of Cu(I) species which is known as the best example of click chemistry.

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References

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