Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Facial Amphiphile 3,7-Diamino-5α-cholestane Derivatives as a Molecular Receptor

  • Ahmad, Md. Wasi (Department of Applied Chemistry, Kyungpook National University) ;
  • Jung, Young-Mee (Department of Applied Chemistry, Kyungpook National University) ;
  • Khan, Sharaf Nawaz (Department of Applied Chemistry, Kyungpook National University) ;
  • Kim, Hong-Seok (Department of Applied Chemistry, Kyungpook National University)
  • Published : 2009.09.20
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Abstract

A series of facial amphiphiles 3,7-diaminocholestane were synthesized from 3,7-diketocholestane via 2 sequential reductive aminations and anion recognition was evaluated with acetate, chloride, bromide, fluoride and phosphate anions. The stereo-selective reductive amination protocol was utilized to synthesized facial amphiphiles afforded receptors in high yields. The molecular receptor 2 showed the highest binding constant with acetate in a 1:1 ratio.

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References

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