Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
권호 표지
DOI QR코드

DOI QR Code

The Effect of Sea Tangle Extract on Serum Lipid Level in Ovariectomized Rats

다시마 추출물이 난소를 절제한 흰 쥐의 혈 중 지질 함량에 미치는 영향

  • Lee, Young-Ae (Dept. of Food Science and Nutrition, Silla University) ;
  • Kim, Mi-Hyang (Dept. of Food Science and Nutrition, Silla University)
  • 이영애 (신라대학교 의생명과학대학 식품영양학과) ;
  • 김미향 (신라대학교 의생명과학대학 식품영양학과)
  • Published : 2008.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

This study was performed to investigate the effects of sea tangle (ST) extracts on serum lipid concentration in ovariectomized rats. Weight-matched female Sprague-Dawley strain rats were assigned to four groups. Three groups were surgically ovariectomized (OVX). The fourth group was sham operated. Rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented with ST at 50 mg/kg body wt (OVX-ST50) and ovariectomized rats supplemented with ST at 200 mg/kg body wt (OVX-ST200). The activities of serum GOT and GPT were increased by ovariectomized. The serum GOT levels in OVX-ST50 and OVX-ST200 groups were decreased than OVX-control group. But GPT level was only decreased in the serum of OVX-ST200 group. Serum total cholesterol and triglyceride contents decreased in sham group compared with OVX-control group by ovariectomy. Six weeks feeding of ST extract resulted in a significant lowering of serum triglyceride and lowering tendency of total cholesterol Level. The serum HDL-cholesterol was higher in ST groups than OVX-control group. These results suggest that the beneficial effect of ST extract may be used to possibly improve on the lipid metabolic syndrome of menopausal women.

폐경 후 여성의 비만은 독특한 생리적 현상으로 음식물 섭취가 촉진되고, 몸무게와 지방조직이 증가되고, 정상 여성보다 혈류 관련 질환 발병이 높아지는 것으로 알려져 있다. 이에 본 연구에서는 갱년기를 유도한 흰쥐에 다시마 추출물을 투여하여 체내 지질 함량 변화에 대해 그 효과를 검토하였다. 그 결과 난소를 절제한 OVX-control군이 난소를 절제하지 않은 Sham군보다 체중이 뚜렷이 증가하는 경향을 보였으며, 다시마 추출물이 체중감소에는 크게 영향을 미치지 않았다. GOT 활성에서는 난소를 절제한 OVX-control군이 난소를 절제하지 않은 Sham군에 비해 GOT 활성이 증가하였으나, 난소를 절제한 후 다시마 추출물 투여에 의해 난소를 절제하지 않은 Sham군보다 GOT활성이 더 감소하는 결과가 나타났다. GPT 활성에서는 난소를 절제 한 후 다시마 추출물을 투여한 군에서는 OVX-control군에 비해 감소하는 경향을 보였는데, 특히 OVX-ST200군에서 감소하는 결과가 나타났다. 난소 절제 후 다시마 추출물 투여는 난소 절제로 인해 야기되는 혈중 총 콜레스테롤의 함량 및 혈청 지질 농도의 증가를 감소시켰다. 또한, HDL-콜레스테롤은 난소절제 군에 비해 난소절제 후 다시마 추출물을 투여하였을 때 혈중 함량이 증가하였다. 이상의 결과에서 다시마 추출물이 갱년기 장애 시 발생할 수 있는 혈 중 지질 함량 변화에 효과가 있는 것으로 나타나 혈류 관련 질환에 대한 개선 식품으로의 활용이 기대된다.

Keywords

References

  1. Baker, H. J., J. R. Lindsey and S. H. Weisbroth. 1984. The laboratory rats. pp. 123-127, Vol.II, Academic Press Inc., New York
  2. Beson, P. B., W. McDermott and J. B. Wyngaarden. 1979. Text book of medicine. pp. 77-100, Saunders Co. philadelphia
  3. Bingham, P. E. 1998. Hormonal treatment of postmenopausal women. N. Eng. J. Med. 22, 330-406
  4. Bush, T. L., E. Barrett-Connor, L. D. Cowan, M. H. Criqui, R. B. Wallace, C. M. Suchindran, H. A. Tyroler and B. M. Rifkind. 1987. Cardiovascular mortality and noncontraceptive use of estrogne in women: results from the lipid research clinics program follow-up study. Circulation 75, 1102-1109 https://doi.org/10.1161/01.CIR.75.6.1102
  5. Campos, H., W. F. Wilson Peter, D. Himenez, J. R. Mcnamara, J. Prdovas and E. J. Schaefer. 1990. Differences in apolipoproteins and low density lipoprptein subfractions in postmenopasusal women on and off estrogen therapy: Results from the Framingham offspring study. Metabolism 39, 1033-1038 https://doi.org/10.1016/0026-0495(90)90162-6
  6. Choi, J. H., C. H. Rhim, J. Y. Kim, J. S. Yang, J. S. CHoi and D. S. Byun. 1986. Basic studies in the development of diet for the treatment of obesity. 1. The inhibitory Effect of alginic acid as a dietary fiber on obesity. Bull. Kor. Fish. Soc. 19, 303-311
  7. Corine, H. R. and S. W. Emma. 1984. Basic nutrition and diet therapy. pp. 272-273, Vol. 5, Macmillan Co., New York
  8. Ebihara, K. and S. Kiriyama. 1990. Physiochemical property and physiological function of dietary fiber. Nippon. Shokuhin. Kogyo. Gakkaishi. 37, 916-925 https://doi.org/10.3136/nskkk1962.37.11_916
  9. Garcia Rodriguez, L. A., G. M. Pfaff, M. C. Schumacher, A. M. Walker. and H. Hoffmeister. 1990. Epidemiology 1, 219-223 https://doi.org/10.1097/00001648-199005000-00007
  10. Geary, N. and L. Asarian. 2001. Am J Physiol Regul Integr Comp. Physilo 1290-1294
  11. Gordon, T., W. K. Kannel and M. C. Hjortl. 1978. Menopause and coronary heart disease. Ann. Int. Med. 89, 157-161 https://doi.org/10.7326/0003-4819-89-2-157
  12. Grady, D., S. M. Rubin, D. B. Petitti, C. S. Fox, D. Black, B. Ettinger, V. L. Ernster and S. R. Cummings. 1992. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann. Intern. Med. 117, 1016-1037 https://doi.org/10.7326/0003-4819-117-12-1016
  13. Hur, J. 1999. Dong-ui-bo-gam. Bupin Publishing Co, Seoul
  14. Ito, K. and Y. Tsuchiya. 1972. The effect of algal polysaccharides on the depressing of plasma cholesterol levels in rat. Inproc proc of 7th Int. Seaweed Symp. Nishizawa K (ed.), Univ. Tokyo Press, Japan. pp. 558-561
  15. Jeong, S. H., H. H. Lee, M. Y. Han, C. Y. Ryu and M. C. Yoon. 2002. Effects of fenofibrate on body weight and lipid metabolism in female mice. Journal of the Institute of Natural Science, Mokwon University 11, 27-32
  16. Jung, Y. T. 2006. Human Psysiolohy. pp. 384-414, 3rd revised, Chungku Press, Seoul
  17. Kang, B. K., S. J. Hwang, D. J. Paik, J. K. Kim and H. S. Chung. 1997. A morphological study on ossification of callus after ribfracture in ovariectomized and estrogen-retreated rats. Han Yang J. Med. 17, 82-91
  18. Kim, H. S. and G. J. Kim. 1998. Effects of the feeding Hijikia fusiforme (Harvey) Okamura on lipid composition of serum in dietary hyperlipidemic rats. J. Kor. Soc. Food. Sci. 27, 718-723
  19. Kim, S. H. and W. K. Park. 1998. Determination and physical properties of dietary fiber in seaweed products. J. Kor. Soc. Food Sci. 17, 320-325
  20. Koh, J. B. and M. A. Choi. 1999. Effects of tea fungus/kombucha on lipid metabolism in streptozotocin-induced diabetic male rats. J. Korean. Soc. Food Sci. 28, 613-618
  21. Lee, J. H. and N. J. Sung. 1983. The content of minerals in algae. J. Kor. Soc. Food Sci.. 12, 51-58
  22. Lee, K. E., Y. J. Park, S. J. Byun, E. K. Yoo, M. L. Lee, Y. S. Lee, H. K. Lee, E. S. Chung, O. S. Cho, E. S. Choi and H. S. Han. 1997. Women health Nursing, Hyunmoonsa, Seoul
  23. Lee, Y. J., Y. K. Kim. et al. 2003. High Science of Nutrition. pp. 76-78, Sinkong Press Inc
  24. Mattson, F. H. and S. M. Grundy. 1985. Comparison of effects of dietary saturated, monounsaturated and to polyunsaturated fatty acids on plasma lipids and lipoorotein in man. J. Lipid Res. 26, 194-202
  25. Mendelsohn, M. E. and R. H. Karas. 1994. Estrogen and the blood vessel wall. Curr. Poin. Cardiol. 9, 619-626 https://doi.org/10.1097/00001573-199409000-00018
  26. National Statistical office. 1997. Annual report on the cause of death statistics, Seoul
  27. Po, A. R., Y. H and T. M. Yoo. 2001. The Effect of isoflavone supplementation on bone metabolism in ovariectomized SD rats. J. Korean. Soc. Food. Sci. Nutr. 30, 657-661
  28. Preuss, H. G. 1993. Nutrition and disease of womne:Cardiovascular disorders. J. Am. Coll. Nutr. 12, 417-425 https://doi.org/10.1080/07315724.1993.10718331
  29. Ramitez, M. E., M. P. McMurry, G. A. Wiebke, K. J. Felton and K. Ren. 1997. Evidence for sex steroid inhibition of lipoprotein lipase in men; comparison of abdominal and femoral adipose tissue. Metabolism 46, 179-185 https://doi.org/10.1016/S0026-0495(97)90299-7
  30. Ross, R. K., A. Pagamm-Hill, T. M. Mark and B. E. Henderson. 1989. Cardiovascular benefits of estrogen replacement therapy. Am. J. Obstet. Gynecol. 160, 1301-1306 https://doi.org/10.1016/S0002-9378(89)80017-1
  31. Shumaker, S. A., C. Legault, L. Kuller, S. R. Rapp, L. Thal and D. S. Lane et al. 2004. For the Wonen's Health Initiative Memory Study Investigators. conjugated equine estrogens and incidence of probable demintia and mild cognitive impaiment in post-menopausal women: women's health initiative memory study. JAMA 291, 2947-2958 https://doi.org/10.1001/jama.291.24.2947
  32. Tashiro, T. 1983. Analysis of nucleic acid related substances of dried purple laver. Bull. Japan. Soc. Sci. Fish. 49, 1121-1125 https://doi.org/10.2331/suisan.49.1121
  33. Valette, A., K. M. Meignen, L. Mercier, J. G. Liehr and J. Boyer. 1986. Effects of 2-fluoroestradiol on lipid metabolism in the ovariectomized rat. J. Steroid. Biochem. 25, 575-578 https://doi.org/10.1016/0022-4731(86)90405-X
  34. Vega, G. L., E. Groszek, R. Wolf and S. M. Grundy. 1982. Influence of PUFA on composition of plasma lipoproteins and apolipoproteins. J. Lipi. Res. 23, 811-822
  35. Women's Health Initiative Steering Committee. 2004. Effects of conjugated equine estrogen in Women's Health Initiative randomized controlled trial. JAMA 291, 1701-1712 https://doi.org/10.1001/jama.291.14.1701
  36. Yim, K. H., K. S. Ahr, D. K. Song and M. B. Wie. 1989. Effects of panax ginseng and radix stragali on age-related physiological alterations in rats. International symposium on east-west medicine

Cited by

  1. Inhibition of Adipocyte Differentiation and Adipogenesis by Supercritical Fluid Extracts and Marc from Cinnamomum verum vol.23, pp.4, 2013, https://doi.org/10.5352/JLS.2013.23.4.510
  2. Anti-obesity Effects of Ishige okamurae Extract in C57BL/6J mice Fed High-fat Diet vol.45, pp.2, 2013, https://doi.org/10.9721/KJFST.2013.45.2.199
  3. Effects of Colpomenia sinuosa Extract on Serum Lipid Level and Bone Formation in Ovariectomized Rats vol.45, pp.4, 2016, https://doi.org/10.3746/jkfn.2016.45.4.492
  4. Anti-obesity Effect of Sargassum confusum Ethanol Extract in Obese Rats vol.43, pp.2, 2011, https://doi.org/10.9721/KJFST.2011.43.2.189