BMB Reports

생화학분자생물학회 (Korean Society for Biochemistry and Molecular Biology)
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An anti-viral peptide derived from the preS1 surface protein of hepatitis B virus

  • Kim, Do-Hyoung (Molecular Cancer Research Center, Division of Molecular Therapeutics, Korea Research Institute of Bioscience and Biotechnology) ;
  • Ni, Yi (University of Heidelberg, Department of Molecular Virology, Otto-Meyerhof-Zentrum (OMZ)) ;
  • Lee, Si-Hyung (Molecular Cancer Research Center, Division of Molecular Therapeutics, Korea Research Institute of Bioscience and Biotechnology) ;
  • Urban, Stephan (University of Heidelberg, Department of Molecular Virology, Otto-Meyerhof-Zentrum (OMZ)) ;
  • Han, Kyou-Hoon (Molecular Cancer Research Center, Division of Molecular Therapeutics, Korea Research Institute of Bioscience and Biotechnology)
  • 발행 : 2008.09.30
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초록

The preS1 surface protein of the hepatitis B virus (HBV) is a key factor involved in initial viral entry into hepatocytes. It has been long postulated that an anti-HBV effect should be achievable using peptide fragments of the preS1. Recent reports demonstrated that several preS1-derived lipo-peptides in genotype D HBV exhibit nano to picomolar inhibitory activity against HBV infection. In this study, an acylated analog of a preS1 fragment, a 21-residue lipo-peptide (named 7524 BVS7) with a sequence of palmitoyl-GMGTNLSVPNPLGFFPDHQLDC-$NH_2$, from genotype C HBV was produced base upon a previous structural study and was shown potently inhibits HBV infection with an $IC_{50}$ of $\approx$ 20 nM.

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참고문헌

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