Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

Biological response of primary rat calvarial cell by surface treatment of Ti-8Ta-8Nb alloy

Ti-8Ta-3Nb 합금의 표면처리에 의한 백서 두개관 세포의 반응

  • Kim, Hae-Jin (Department of Periodontology, School of Dentistry, Chonnam National University) ;
  • Son, Mee-Kyoung (Department of Prosthodontics, College of Dentistry, Chosun University) ;
  • Park, Ji-Il (Department of Dental hygiene, Gwangju Health College) ;
  • Chung, Hyun-Ju (Department of Periodontology, School of Dentistry, Chonnam National University) ;
  • Kim, Young-Joon (Department of Periodontology, School of Dentistry, Chonnam National University)
  • 김해진 (전남대학교 치의학전문대학원 치주과학교실, 전남대학교 치의학 연구소) ;
  • 손미경 (조선대학교 치과대학 보철학교실) ;
  • 박지일 (광주보건전문대학 치위생과) ;
  • 정현주 (전남대학교 치의학전문대학원 치주과학교실, 전남대학교 치의학 연구소) ;
  • 김영준 (전남대학교 치의학전문대학원 치주과학교실, 전남대학교 치의학 연구소)
  • Published : 2008.12.31
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Abstract

Purpose: Ti-6Al-4V alloy is widely used as an implant material because of its good biocompatibility and good mechanical property compared with commercial pure titanium. Otherwise, toxicity of aluminum and vanadium in vivo has been reported. Ti-8Ta-3Nb alloy is recently developed in the R&D Center for Ti and Special Alloys and it was reported that this alloy has high mechanical strength, no cytotoxicity and similar biocompatibility to commercial pure titanium, but many studies are needed for its clinical use. In these experiment, we carried out different surface treatment on each Ti-8Ta-3Nb alloy disks, then cultured cell on it and assessed biological response. Materials and Methods: cpTi, Ti-6Al-4V, Ti-8Ta-3Nb alloy disks were prepared and carried out sandblasting and acid etching (SLA) or alkali-heat treatment (AH) on the Ti-8Ta-3Nb alloy disks. We cultured primary rat calvarial cells on each surface and assessed early cell attachment and proliferation by scanning electron microscopy, cell proliferation, alkaline phosphatase activity. Result: The rates of cell proliferation on the cpTi, Ti-8Ta-3Nb AH disks were higher than others (p<0.05) and alkaline phosphatase activity was significantly enhanced on the Ti-STa-8Nb AH disks(p<0.05). Conclusion: Most favorable cell response was shown on the Ti-8Ta-3Nb AH surfaces. It is supposed that alkali-heat treatment of the Ti-8Ta-3Nb alloy could be induced earlier bone healing and osseointegration than smooth surface.

Keywords

References

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