The Korea Journal of Herbology (대한본초학회지)
- Volume 22 Issue 2
- /
- Pages.175-180
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- 2007
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
Effects of Samso-Eum on cytokine productions in asthmatic mice
삼소음(蔘蘇飮)이 천식이 유발된 생쥐의 cytokine 분비에 미치는 영향
- Kim, Hyung-Woo (College of Oriental medicine, Dongshin University) ;
- Cho, Su-Jin (College of medicine, Korea University) ;
-
Kim, Bu-Yeo
(College of Oriental medicine, Dongshin University)
;
- Baek, Jin-Woong (College of Oriental medicine, Dongshin University) ;
-
Jeong, Hyun-Woo
(College of Oriental medicine, Dongshin University)
;
-
Cho, Su-In
(College of Oriental medicine, Dongshin University)
- 김형우 (동신대학교 한의과대학) ;
- 조수진 (고려대학교 의과대학) ;
-
김부여
(동신대학교 한의과대학)
;
- 백진웅 (동신대학교 한의과대학) ;
-
정현우
(동신대학교 한의과대학)
;
-
조수인
(동신대학교 한의과대학)
- Published : 2007.06.30
Abstract
Objective : The application of Sam So Eum (蔘蘇飮, SSE) as a herbal medicine to treat asthma in mice has been studied and the mechanism of cytokine production in asthmatic mice was discussed. Recently, SSE was known to have anti-allergic activity. However, its therapeutic mechanisms are unclear. Methods : So, we investigated the effects of SSE on levels of several cytokines in bronchoalveolar lavage fluid (BALF) using flow cytometric analysis in allergen-induced asthma. Results : In this experiment, SSE decreased levels of IL-la, IL-17 and GM-CSF respectively. Contrary, SSE restored level of IFN-g toward naive level in BALF. Conclusion : In conclusion, we demonstrate that SSE is useful to treat asthma and it's therapeutic mechanisms are involved in Thl skewing reaction.