The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Study on the Attributive Channel Theory by the Pharmacodynamic Research of I-131 labelled Curcumin

I-131 표지 Curcumin의 약동력학적 분석을 통한 귀경(歸經)연구

  • Yun, Hong-Il (College of Oriental Medicine, Kyunghee University) ;
  • Ham, In-Hye (College of Oriental Medicine, Kyunghee University) ;
  • Cho, Jung-Hyuck (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Yu, Kook-Hyun (College of Science, Dongkook University) ;
  • Park, Jung-Hoon (College of Science, Dongkook University) ;
  • Choi, Ho-Young (College of Oriental Medicine, Kyunghee University)
  • 윤홍일 (경희대학교 한의과대학) ;
  • 함인혜 (경희대학교 한의과대학) ;
  • 조정혁 (한국과학기술연구원 의약화학연구센터) ;
  • 유국현 (동국대학교 이과대학) ;
  • 박정훈 (동국대학교 이과대학) ;
  • 최호영 (경희대학교 한의과대학)
  • Published : 2007.06.30
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Abstract

Objectives : This study was to verify the Attributive Channel theory of herbal medicine. Methods : [13lI]iodocurcumin was synthesized, separated, and refined from curcumin, the major component of Curcuma species, followed by observing the biodistribution in an organism. Especially, from the fact that curcumin has shown to possess potent anti-carcinogenic properties, the biodistribution in the carcinogenesis organism was analyzed. Result : Iodocurcumin 23mg was obtained through column chromatography after a reaction with 50mg of Curcumin and ICl. The nominal yield of [13lI]iodocurcumin synthesis was 35% when checked with radioactive layer of chromatography. [13lI]iodocurcumin was most largely distributed in the stomach of a BALB/c mouse and a C57BL/6 mouse transplanted with Lewis lung carcinoma cell. Conclusion : The fact that [13lI]iodocurcumin was most largely distributed in the stomach was related with the Attributive Channel theory. And there was no significant finding related to tumor cells.

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