Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Validity of MAST-CLA for diagnosis of arthropod allergy using receiver operating characteristic (ROC) analysis

  • Park, Joon-Soo (Department of Pediatrics, Soonchunhyang University) ;
  • Nam, Hae-Seon (Department of Clinical Parasitology, Soonchunhyang University) ;
  • Kim, Yong-Bae (Department of Preventive Medicine, Soonchunhyang University) ;
  • Choi, Young-Jin (Department of Laboratory Medicine, Soonchunhyang University) ;
  • Lee, Sang-Han (Department of Biochemistry, College of Medicine, Soonchunhyang University) ;
  • Kim, Sung-Ho (Department of Chemistry, College of Natural Science, Soonchunhyang University)
  • Published : 2007.09.30
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Abstract

Many allergists are currently focusing on the development of new diagnostic tools, and are attempting to improve both the sensitivity and specificity. A multiple allergen simultaneous test-chemiluminescent assay (MAST-CLA) is one of the most popular diagnostic tools used in the Republic of Korea. However, there remains controversy among allergists with regard to the cut-off point for a positive result. The present study was conducted in order to determine the validity of MAST-CLA as compared with that of the skin prick test, with particular emphasis on arthropod allergens, on the basis of percentage agreement rates and k-values, and also to suggest the optimal positive cutoff points using receiver operating characteristic (ROC) curves. The study was conducted with 97 subjects (54 men, 43 women). Optimal individual cut-off points were calculated as follows; class II for Dermatophagoides farinae, class I for Dermatophagoides pteronyssinus, and trace for a cockroach mix. These findings suggest that attempting to apply optimal individual cut-off points will be a good way of improving diagnostic tests, particularly MAST-CLA.

Keywords

References

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