• Journal of Digestive Cancer Research
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• v.10 no.2
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• pp.99-106
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• 2022

Clinical research ultimately aimed to promptly diagnose and prevent diseases through precise biomarker development. Finding the optimal cut-off point of a regularly measured biomarker can help its interpretation and ultimately help in disease investigation and diagnosis, more specifically in determining the presence of diseases. Therefore, this study aimed to use the characteristics of outcome variables in clinical research to explain how to determine the optimal cutoff point. The outcome variables can be divided into dichotomous, ordinal, and survival types. The optimal cut-off point can be determined by finding points that maximize the Youden index, extended Youden index, and log-rank statistics. This study will enable clinical researchers to accurately determine the optimal cut-off points for regularly measured biomarkers, thereby enabling prompt disease diagnosis for effective treatment.

• Journal of Environmental Health Sciences
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• v.47 no.4
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• pp.320-329
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• 2021

Background: Smoking exposure may be objectively assessed through specific biomarkers. The most common biomarker for smoking is cotinine concentration in urine, and setting an optimal cut-off point can accurately classify smoking status. Such a cut-off point for Korean adolescents has never been studied. Objectives: The aim of this study was to determine a cut-off point for urinary cotinine concentration for the discrimination of smoking in adolescents. Methods: Participants were adolescents aged 13~18 years who participated in the third cycle of the Korean National Environmental Health Survey. We used urine samples to confirm the level of cotinine concentrations. Smoking status was determined by self-reported questionnaire. We identified the optimal cotinine cut-off point for discriminating smoking status using receiver operating characteristic curve analysis. Results: Of the 904 participants, 28 (3.1%) were smokers, among whom 20 (71.4%) were male. The median urinary cotinine concentrations in smokers was 218 ㎍/L (male: 215 ㎍/L, female: 303 ㎍/L), and that in non-smokers was 1.31 ㎍/L (male: 1.46 ㎍/L, female: 1.18 ㎍/L). We found significant differences in urinary cotinine concentration according to smoking status and sex (p<0.001). Urinary cotinine concentrations performed well for identifying smoking adolescents [area under the curve: 0.954 (male: 0.963, female: 0.908)]. The cut-off that optimally distinguished smokers from non-smokers was 39.85 ㎍/L (sensitivity: 89.3%, specificity: 97.4%). Male [39.85 ㎍/L (sensitivity: 90.0%, specificity: 94.9%)] had a different optimal cut-off point than female [26.26 ㎍/L (sensitivity: 87.5%, specificity: 99.6%)]. Conclusions: This study determined a cut-off point for urinary cotinine of 39.85 ㎍/L (male: 39.85 ㎍/L, female: 26.26 ㎍/L) to distinguish smokers from non-smokers in adolescents.

• Proceedings of the Korean Society for Language and Information Conference
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• 2007.11a
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• pp.126-135
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• 2007

We propose and test several computational methods to automatically determine possible saliency cut-off points in Sketch Engine (Kilgarriff and Tugwell, 2001). Sketch Engine currently displays collocations in descending importance, as well as according to grammatical relations. However, Sketch Engine does not provide suggestions for a cut-off point such that any items above this cut-off point may be considered significantly salient. This proposal suggests improvement to the present Sketch Engine interface by calculating three different cut-off point methods, so that the presentation of results can be made more meaningful to users. In addition, our findings also contribute to linguistic analyses based on empirical data.

• Journal of Broadcast Engineering
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• v.15 no.6
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• pp.845-852
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• 2010

Collecting statistics from client requests, the broadcast server partitions data items into hot and cold-item sets with the optimal cut-off point. Hot items are broadcast periodically with periods based on their access probabilities. In a time slot with no hot items scheduled, the server broadcasts a proper cold item considering the waiting time and the number of outstanding requests. We analyze the optimal the cut-off point by calculating average response time as a function of the cut-off point. Simulation results show that our proposed algorithm outperforms existing methods in various circumstances.

• The Korean Journal of Applied Statistics
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• v.27 no.3
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• pp.501-512
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• 2014

Modified cut-off sampling is widely used for highly skewed data. A serious drawback of modified cut-off sampling is the difficulty of adjustment of non-response in take-all stratum. Therefore, solutions of the problems of non-response in take-all stratum have been studied in various ways such as substitute of samples, imputation or re-weight method. In this paper, a new cut-off point based on minimizing MSE being used in exponential and power functions is suggested and it can be reduced the number of take-all stratum. We also investigate another cut-off point determination method with underlying distributions such as truncated log-normal and truncated gamma distributions. Finally we suggest the optimal cut-off point which has a minimum of take-all stratum size among suggested methods. Simulation studies are performed and Labor Survey data and simulated data are used for the case study.

• The KSFM Journal of Fluid Machinery
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• v.13 no.3
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• pp.37-42
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• 2010

This study investigated on details of flow characteristics of a multi-blade fan for domestic ventilation. Experiments and analysis were carried out to describe on flow pattern with variations of cut-off angle near the scroll housing throat, which were performed by PIV measurement for the flow field and by total pressure probes. The stagnation point at cut-off region of the fan moves to the exit of the scroll housing as the cut-off angle increases. The movement of stagnation point and the variation of throat area of the scroll housing influence to the distribution of velocity magnitude at the exit of the fan. Furthermore, a large distortion of the velocity distribution at the scroll exit causes to increase mixing loss along the flow path.

• Journal of Korea Multimedia Society
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• v.21 no.7
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• pp.772-778
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• 2018

We have previously proposed a preliminary cut-off indoor positioning scheme considering the reference point with the same signal similarity. This scheme estimates the position using the relative rank of the peak of received signal strength from the beacons around user. However, this scheme has a weak point with lower accuracy when there are more than one nearest reference points having the same signal similarity. In order to tackle this, we propose a weighted preliminary cut-off indoor positioning scheme. Firstly, if the above problem occurs, the similarity to the peak of signal strength is considered as well as the relative rank. Next, weights are assigned to the nearest reference points using the similarity to the peak of the received signal strength. Finally, the user's position is estimated by applying the weights. As a result, the weighted preliminary cut-off scheme improves the positioning accuracy by about 7.9% compared to the previous scheme.

• Journal of Korea Multimedia Society
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• v.20 no.1
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• pp.74-81
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• 2017

In learning stage of the preliminary Cut-off indoor positioning scheme, RSSI and UUID data received from beacons at each reference point(RP) are stored in fingerprint map. The fingerprint map and real-time beacon information are compared to identify the nearest K reference points through which the user position is estimated. If the number of K is zero, this scheme cannot estimate user position. We have improved the preliminary Cut-off scheme to get the estimated user position even in the case. The improved scheme excludes the beacon of the weakest signal received by user mobile device and identifies neighborhood reference points using the other beacon information. This procedure are performed repetitively until K > 0. The simulation results confirm that the proposed scheme outperforms K-Nearest-Neighbor (KNN), Cluster KNN and the conventional Cut-off scheme in terms of accuracy while the constraints are guaranteed to be satisfied.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.200-200
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• 2011

Although the cut-off probe, a precise measurement method for the electron density, is widely used in the industry, the physics on the wave spectrum of the cut-off is not understood yet, only cut-off point frequency containing the information of electron density has been analyzed well. This paper analyzes the microwave frequency spectrum of the cut-off probe to see the physics behind using both microwave field simulation (CST Microwave Studio) and simplified circuit simulation. The result shows that the circuit model well reproduces the cut-off wave spectrum especially in the low frequency regime where the wavelength of the driving frequency is larger than the characteristic length and reveals the physics of transmission characteristics with frequency as resonances between vacuum, plasma and sheath. Furthermore, by controlling the time domain in solver of the microwave simulator, the cut-off like transmission peaks above the cut-off frequency which has been believed as cavity effect is verified as chamber geometry effect. The result of this paper can be used as the basis for the improvement of cut-off probe.

• Journal of radiological science and technology
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• v.26 no.2
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• pp.63-69
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• 2003

Filtering is necessary to reduce statistical noise and to increase image quality in SPECT images. Noises controled by low-pass filter designed to suppress high spatial frequency in SPECT image. Most SPECT filter function control the degree of high frequency supression by chosing a cut of frequency. The location of cut off frequency determines the affect image noise and spatial resolution. If select the low cut off frequency, its provide good noise suppression but insufficient image quantity and high cut off frequencies increase the image resolution but insufficient noise suppression. The purpose of this study was to determines the optimam cut off level with comparison of FWHM according to cut off level in each kiters-Band-limited, Sheep-logan, Sheep-logan Hanning, Generalized Hamming, Low pass cosine, Parazen and Butterworth filter in SPECT camera. We recorded image along the X, Y, Z-axis with $^{99m}TcO_4$ point source and measured FWHM by use profile curve. We find averaged length is $9.16\;mm{\sim}18.14\;mm$ of FWHM in X, Y, and Z-axis, and Band-limited and Generalized Hamming filters measures 9.16 mm at 0.7 cycle/pixel cut off frequency.