Tissue response of Pro-Root® MTA with rhBMP-2 in pulpotomized rat teeth

백서에서 치수 절단술 시행 시 Pro-Root® MTA 단독 사용군과 rhBMP-2 혼용 사용군 간의 조직 반응 비교 연구

  • Park, Kyung-Tae (Division of Conservative Dentistry, Department of Dentistry, Asan Medical Center, Ulsan University) ;
  • Yang, Won-Kyung (Division of Conservative Dentistry, Department of Dentistry, Asan Medical Center, Ulsan University) ;
  • Ko, Hyun-Jung (Division of Conservative Dentistry, Department of Dentistry, Asan Medical Center, Ulsan University) ;
  • Kim, Mi-Ri (Division of Conservative Dentistry, Department of Dentistry, Asan Medical Center, Ulsan University)
  • 박경태 (울산대학교 의과대학 서울 아산병원 보존과) ;
  • 양원경 (울산대학교 의과대학 서울 아산병원 보존과) ;
  • 고현정 (울산대학교 의과대학 서울 아산병원 보존과) ;
  • 김미리 (울산대학교 의과대학 서울 아산병원 보존과)
  • Published : 2007.09.29


The purpose of this study was to investigate whether rhBMP-2 (BMP2) could induce synergistic effect with $Pro-Root^{(R)}$ MTA (MTA) in pulpotomized teeth in the rats. Healthy upper first molars from thirty-two, 10 weeks old, Sprague-Dawley rats were used for this investigation. The molars were exposed with round bur, and light pressure was applied with sterilized cotton to control hemorrhage. 1.2 grams of MTA cement was placed in right first molars as a control group. In left first molars, $1\;{\mu}g$ of BMP2 was additionally placed on exposed pulps with MTA. All cavities were back-filled with light-cured glass-ionomer cements. The rats were sacrificed after 2 weeks and 7 weeks, respectively. Then histologic sections were made and assessed by light microscopy. Data were statistically analyzed via student t-test with SPSSWIN 12.0 program (p < 0.05). Inflammation observed in 2 weeks groups were severe compared to the 7 weeks groups. But the differences were not statistically significant. BMP2-addition groups had less inflammation than MTA groups in both periods, though these differences were also not statistically significant. In conclusion, the combination of BMP2 and MTA showed no differences with MTA only for pulpotomy of rat teeth.


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