Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
권호 표지
DOI QR코드

DOI QR Code

Formulation of Sustained Release Granule for Venlafaxine-HCl Using Water-Insoluble Polymer

수불용성 고분자를 이용한 염산벤라팍신의 서방형 과립 설계

  • Park, Ji-Seon (Laboratory of Industrial Pharmacy, Chungnam National University) ;
  • Seo, Jin-A (Department of Information & Biomaterials, Hannam University) ;
  • Jeong, Sang-Young (Laboratory of Industrial Pharmacy, Chungnam National University) ;
  • Yuk, Soon-Hong (Department of Information & Biomaterials, Hannam University) ;
  • Shin, Byung-Cheol (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Hwang, Sung-Joo (Laboratory of Industrial Pharmacy, Chungnam National University) ;
  • Cho, Sun-Hang (Laboratory of Industrial Pharmacy, Chungnam National University)
  • 박지선 (충남대학교 약학대학 제제공학실) ;
  • 서진아 (한남대학교 생명정보 신소재공학과) ;
  • 정상영 (충남대학교 약학대학 제제공학실) ;
  • 육순홍 (한남대학교 생명정보 신소재공학과) ;
  • 신병철 (한국화학연구원 나노생체재료팀) ;
  • 황성주 (충남대학교 약학대학 제제공학실) ;
  • 조선행 (한국화학연구원 나노생체재료팀)
  • Published : 2007.04.21
Download PDF
⟨ Previous Next ⟩

Abstract

Venlafaxine, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride is a novel, nontricyclic antidepressant. venlafaxine is a unique antidepressant that differs structurally from other currently available. The aim ot the study was to formulate sustained-release venlafaxine granules and assess their formulation variables. It consists of two layers, venlafaxine drug layer and sustained release coating layer and manufactured by fluidized bed process. The sustained release of drug could be increased by double-control rising various components in venlafaxine drug layer and sustained-release layer. The drug-containing granules were coated with cellulose acetate, cetyl alcohol and Eudragit RS along with plastisizer such as dibuthyl sebacate as an nano-pore former The release oi venlafaxine depended on the type of Eudragit such as RS, and RL used in the formulation of controlled release layer. These results obtained clearly suggest that the sustained release oral delivery system for venlafaxine could be designed with satisfying drug release profile approved.

Keywords

References

  1. B. K. Kang, G. Khang, J. M. Kim, S. Y. Jeung, H. B. Lee and S. H. Cho, Release and characterization of multiple coated pellets containing melatonin, J .Kor. Pharm. Sci., 33(3), 179-185 (2003)
  2. G. Khang, J. C. Cho, J. W. Lee, J. M. Rhee and H. B. Lee, Preparation and characterization of Japanese encephalitis virus vaccine loaded poly(L-lactide-co-glycolide) microspheres for oral immunization, Bio-Med. Mater. Eng., 9, 49-59 (1999)
  3. J. C. Cho, G Khang, H. S. Choi, J. M. Lee and H. B. Lee, Preparation of biodegradable PLGA microspheres for sustained local anesthesia and their in vitro release behavior, polymer (Korea), 24(5), 728-735 (2000)
  4. G. Khang, H. Choi, J. C. Cho, S. C. Yoon, J. M. Rhee and H. B. Lee, Controlled release of gentamicin sulfate from poly(3-hydroxybutyrate-co-3-hydroxyvalenrate) wafers for the treatment of osteomyelitis, Korea polymer J., 8(6), 253-260 (2000)
  5. G. Khang, S. W. Kim, J. C. Cho, J. M. Rhee, S. C. Yoon, and H. B. Lee, Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyvalenrate) microspheres for the sustained release of 5-fluorouracil, Bio-Med. Mater. Eng., 11, 89-103 (2001)
  6. D. Stephens, L. Li, D. Robinson, S. Chen, H. Chang, R. M. Liu, Y. Tian, E. J. Ginsburg, X. Gao and T. Stultz, Investigation of the in vitro release of gentamicin from a polyanhydride matrix, J. Control. Rel., 63, 305-317 (2000) https://doi.org/10.1016/S0168-3659(99)00205-9
  7. Y. Ikada, S. H. Hyon, K. Jamshidi, S. Higashi, T. Yamamuro, Y. Katutani and T. Kitsugi, Release of antibiotic from composites of hydroxyapatite and poly(lactic acid), J. Control. Rel., 2, 179-186 (1985) https://doi.org/10.1016/0168-3659(85)90043-4
  8. G. Khang, J. H. Lee, J. W. Lee, J. C. Cho and H. B. Lee, Preparation and characterization of poly(L-lactide-co-glycolide) microspheres for the sustained release of AZT, Korea polymer J., 8(2), 80-88 (2000)
  9. K. H. Park, Clinical application of drug delivery system, J. Korean Soc. Hosp. Pharm. PP, 9(3), 194-208 (1992)
  10. G. Tournel, N. Houdret, V. Hedouin, M. Deveaux, D. Gosset, M. Lhermitte, High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum, J. Chromatogra B, 761, 147-158 (2001) https://doi.org/10.1016/S0378-4347(01)00305-X
  11. Mary A. Gutierrez, Glen L. Stimmel and Janet Y. Aiso, New drugs; Venlafaxine : A 2003 Update, 25(8), 2138-2154 (2003)
  12. Sapna N. Makhija, and Pradeep R. Vavia, Stability indicating LC method for the estimation of venlafaxine in pharmaceutical formulations, J. Pharmaceutical and Biomedical Analysis, 28, 1055-1059 (2002) https://doi.org/10.1016/S0731-7085(01)00701-4
  13. M. Matogaa, F. Pehourcqb, K. Titierb, F. Dumorab and C. Jarrya, Rapid high-performance liquid chromatographic measurement of venlafaxine and O-desmethylvenlafaxine in human plasma application to management of acute intoxications, J. Chromatography B, 760, 213-218 (2001) https://doi.org/10.1016/S0378-4347(01)00270-5
  14. S. M. Seo, H. S. Lee, J. Lee, H. Y Lee, B. Lee, H. B. Lee and S. H. Cho, Controlled Release of Tamsulosin from Nanopore-Forming Granules, J. Kor. Pharm. Sci., 36(1) 39-44 (2006)