The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Antifatigue Effect of Chlorella vulgaris in Mice

클로렐라의 항 피로 효과 연구

  • An Hyo-Jin (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Seo Sang-Wan (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Sim Kyung-Sik (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kim Jung-Suk (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Kim Eun-Hee (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Lee Mi-Ok (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Park Hyeung-Suk (Daesang Corp. WellLife R&D Center) ;
  • Han Jae-Gab (Daesang Corp. WellLife R&D Center) ;
  • Lee Eun-Hee (Division of Beauty Arts, Jeonbuk Science College) ;
  • Um Jae-Young (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Hong Seung-Heon (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kim Hyung-Min (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
  • 안효진 (경희대학교 한의과대학.한의학연구소) ;
  • 서상완 (원광대학교 약학대학 한약학과) ;
  • 심경식 (원광대학교 약학대학 한약학과) ;
  • 김정숙 (경희대학교 한의과대학.한의학연구소) ;
  • 김은희 (경희대학교 한의과대학.한의학연구소) ;
  • 이미옥 (원광대학교 약학대학 한약학과) ;
  • 박형석 (대상 웰라이프 R&D 센터) ;
  • 한재갑 (대상 웰라이프 R&D 센터) ;
  • 이은희 (전북과학대학 미용예술계열) ;
  • 엄재영 (경희대학교 한의과대학.한의학연구소) ;
  • 홍승헌 (원광대학교 약학대학 한약학과) ;
  • 김형민 (경희대학교 한의과대학.한의학연구소)
  • Published : 2006.06.01
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Abstract

A unicellular algae, Chlorella vulgaris(CV), was used as a biological response modifier. The effect of CV on forced swimming test and blood biochemical parameters related to fatigue was investigated. Blood urea nitrogen(BUN); creatine kinase(CK); lactic dehydrogenase(LDH); glucose(Glc); total protein(TP); and albumin were determined. CV was orally administered to mice in the range of 0.05 to 0.15 g/kg/day. A forced swimming test results on 3 and 7 day after administration of CV, showed that immobility time was decreased in the CV-administered group(0.15 g/kg). In addition, the contents of BUN in the blood serum were decreased in CV-fed group. The contents of CK and LDH were tended to decrease, but not statistically significant. The plasma Glc level was increased in CV-fed groups(0.05 and 0.1 g/kg) compared to control group. It had no effect on the elevation of TP and albumin level. The results indicate that CV could improve physical stamina.

단세포 조류 생물인 Chlorella vulgaris(클로렐라)는 다양한 생리 활성을 가진 기능성 소재로 이용되고 있다. 본 연구에서는 강제 수영 부하 실험과 혈액 생화학적 지표에 대한 클로렐라의 효과에 대해 연구하였다. 혈액 생화학적 지표로는 Blood urea nitrogen(BUN), creatine kinase(CK), lactic dehydrogenase(LDH), glucose(Glc), total protein(TP), albumin을 혈액 생화학적 지표로 측정하였다. 매일 0.05, 0.1, 0.15 g/kg 농도의 클로렐라를 각각 실험 군별로 마우스에 구강 투여했다. 클로렐라를 투여한지 3일, 7일째 되는 날 강제 수영 부하 실험을 시행한 결과 0.15 g/kg 클로렐라를 투여한 그룹에서 유의적으로 부동시간을 감소시켰다. 또한 혈청 중 BUN 수치를 낮췄으며, CK, LDH 수치는 감소하는 경향을 나타냈다. 클로렐라 투여 시 혈 중 Glc 수치는 높아졌으나, TP 와 albumin 수치는 변화가 없었다. 이상의 결과들은 클로렐라가 육체적 지구력 향상 효과가 있는 것을 시사하고 있다.

Keywords

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