Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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AdoMet Derivatives Induce the Production of Actinorhodin in Streptomyces coelicolor

  • Lee Yu-Kyung (Bio/Molecular Informatics Center, Konkuk University) ;
  • Young Jung-Mo (Bio/Molecular Informatics Center, Konkuk University) ;
  • Kwon Hyung-Jin (Institute of Bioscience and Biotechnology and Department of Biological Science, Myongji University) ;
  • Suh Joo-Won (Institute of Bioscience and Biotechnology and Department of Biological Science, Myongji University) ;
  • Kim Jin-Young (Department of Molecular Biotechnology, Konkuk University) ;
  • Chong You-Hoon (Department of Molecular Biotechnology, Konkuk University) ;
  • Lim Yoong-Ho (Bio/Molecular Informatics Center, Konkuk University)
  • Published : 2006.06.01
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Abstract

Exogenous S-adenosyl-L-methionine (AdoMet) enhances the production of actinorhodin in Streptomyces coelicolor. Thirty compounds related structurally with AdoMet were tested for their actinorhodin production. The relationships between the structures of the compounds tested and their actinorhodin production were analyzed using computational methods, and the molecules containing both bulky substituents at the C6 position of adenine and the long 5'-alkyl chain of adenosine were predicted to show high actinorhodin production.

Keywords

References

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