Pediatric Gastroenterology, Hepatology & Nutrition
- 제9권1호
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- Pages.48-57
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- 2006
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- 2234-8646(pISSN)
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- 2234-8840(eISSN)
소아 비만에서 Leptin, Adiponectin 및 Leptin/Adiponectin Ratio와 대사 장애의 연관성에 관한 연구
Correlations of Leptin, Adiponectin and Leptin/Adiponectin Ratio with Metabolic Disorders in the Childhood Obesity
- Cho, Sung Jong (Department of Pediatrics, Chosun University College of Medicine) ;
- Kim, Eun Young (Department of Pediatrics, Chosun University College of Medicine) ;
- Moon, Kyung Rye (Department of Pediatrics, Chosun University College of Medicine)
- 투고 : 2006.01.31
- 심사 : 2006.02.25
- 발행 : 2006.03.01
초록
목 적: 연구자는 adipocytokine의 일종인 leptin, adiponectin과 leptin/adiponectin 비를 이용하여 비만아에서 신체 계측치와 인슐린, 지질 농도와의 상관관계를 알아보고자 한다. 방 법: 2005년 1월부터 2005년 6월까지 조선대학교병원 소아과에 방문한 BMI 95백분위수 이상인 7~15세 사이의 비만군 25명(남: 20명, 여: 5명)과 정상 체중 아동인 대조군 25명(남: 20명, 여: 5명)을 대상으로 하였다. 신체 계측(신장, 체중, 팔둘레, 피부주름두께, 체지방률)을 시행하고 공복상태에서 채혈하여 adiponectin, leptin과 혈당, 인슐린, 지질 농도를 측정하였다. 통계는 Student t-test와 Pearson's correlation coefficient 분석법을 이용하였다. 결 과: 비만군에서 대조군에 비해 체질량 지수, 체지방률, 팔둘레, 삼두박근 피부주름두께 및 견갑골하 피부주름두께가 대조군에 비해 유의하게 높았고, 인슐린 농도(
Purpose: To investigate the correlation of the serum leptin, adiponectin, and leptin/adiponectin ratio with metabolic disorders in the childhood obesity. Methods: Fifty children (25 obese and 25 non-obese) were recruited in the pediatric outpatient clinic of Chosun University Hospital from January 1st to June 30th 2005. Adiponectin, leptin, anthropometric parameters, glucose, LDL-cholesterol, HDL-cholesterol, total cholesterol, triglyceride, and insulin levels were measured. The correlations of leptin and adiponectin levels with anthropometric parameters, glucose, insulin and lipids were analyzed by Pearson's correlation coefficients. Results: Insulin and leptin levels of the obese group were significantly higher than those of the non-obese group (p<0.05, p<0.001 respectively). HDL-cholesterol and adiponectin levels of the obese group were significantly lower than those of the non-obese group (p<0.005, p<0.05 respectively). In the obese group, leptin level was positively correlated with BMI and the percentage of body fat, but negatively correlated with adiponectin level. Moreover, adiponectin level of the obese group was negatively correlated with BMI and the percentage of body fat, but positively correlated with leptin level. In the non-obese group, only insulin level was positively correlated with adiponectin. In the obese group, leptin/adiponectin ratio was positively correlated with the percentage of body fat and leptin level. Also, leptin/adiponectin ratio was positively correlated with BMI and the percentage of body fat in the non-obese group. Conclusion: Leptin, adiponectin, and leptin/adiponectin ratio did not appear to have a major role linking various metabolic disorders in the childhood obesity, even though they were strongly associated with obesity indices. Also, leptin/adiponectin ratio was associated with obesity indices even in non-obese children.