Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Single Oval Dose Toxicity Study of the Extract of Aralia elata in Mice

마우스에서 두릅 추출물의 단회경구투여 독성시험

  • Yang, Hee-Kyoung (Department of Veterinary Medicine Cheju National University) ;
  • Jin, Ju-Youn (Department of Veterinary Medicine Cheju National University) ;
  • Kim, Ji-Min (Department of Veterinary Medicine Cheju National University) ;
  • Ko, Mun-Su (Department of Veterinary Medicine Cheju National University) ;
  • Hong, Hyun-Ju (Department of Veterinary Medicine Cheju National University) ;
  • Kim, Sang-Chul (Department of Veterinary Medicine Cheju National University) ;
  • Lee, Young-Jae (Department of Veterinary Medicine Cheju National University)
  • Published : 2006.12.30
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Abstract

This study was conducted to investigate the potential acute toxicity of Aralia elata by a single oral dose in ICR mice. Thirty mice of each sex were randomly assigned to three groups of 10 mice each. The test articles were administered once by the gavage to mice at dose levels of 0, 2,500 and 5,000 mg/kg body weight. The mortality and changes on body weight and clinical signs of gross observation were monitored for 14 days after dosing. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem examinations were performed. There were no dead animal and adverse effects on clinical signs, the body weight and the gross finding. As the results, we could not find any toxic effect at the dose levels of 2,500 or 5,000 mg/kg in mice and the minimal lethal dose was considered to be over 5,000 mg/kg body weight in mice.

Keywords

References

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