Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and Evaluation of Biological Properties of Benzylide-neacetophenone Derivatives

  • Oh, Sei-Kwan (Department of Neuroscience, College of Medicine, Ewha Womans University,Medical Science Institute, Ewha Womans University) ;
  • Jang, So-Yong (Department of Neuroscience, College of Medicine, Ewha Womans University) ;
  • Kim, Dong-Hyun (Medical Science Institute, Ewha Womans University) ;
  • Han, Inn-Oc (Department of Physiology, College of Medicine, Inha University) ;
  • Jung, Jae-Chul (Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi)
  • Published : 2006.06.01
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Abstract

A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.

Keywords

References

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