The Korea Journal of Herbology (대한본초학회지)
- Volume 21 Issue 2
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- Pages.159-163
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- 2006
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
A 4-weeks Oral Toxicity of Dangguibohyel-tang in Sprague-Dawley Rats
당귀보혈탕(當歸補血湯)의 SD계 흰쥐에 대한 아급성경구독성시험
- Kang, Soon-Ah (Dept. of Fermented Food Science, Seoul University of Venture & Information) ;
- Chang, Mun-Seog (Department of Medicine, Division of Newborn Medicine, Children's Hospital and Harvard Medical School) ;
-
Oh, Myung-Sook
(College of Oriental Medicine, Kyung Hee University)
;
-
Park, Wan-Su
(College of Oriental Medicine, Kyung Hee University)
;
-
Kim, Won-Nam
(College of Oriental Medicine, Kyung Hee University)
;
-
Yang, Woog-Mo
(College of Oriental Medicine, Kyung Hee University)
;
-
Lee, Byong-Hee
(College of Oriental Medicine, Kyung Hee University)
;
-
Park, Seong-Kyu
(College of Oriental Medicine, Kyung Hee University)
- 강순아 (국군벽제병원 한방과) ;
- 장문석 (서울대학교 물리학부 한의학물리 연구실) ;
-
오명숙
(경희대학교 한의과대학)
;
-
박완수
(경희대학교 한의과대학)
;
-
김원남
(경희대학교 한의과대학)
;
-
양웅모
(경희대학교 한의과대학)
;
-
이병희
(경희대학교 한의과대학)
;
-
박성규
(경희대학교 한의과대학)
- Published : 2006.06.30
Abstract
Objectives : The subacute toxicity was investigated in Sprague-Dawley rats orally treated with Dangguibohyel-tang (DBT). DBT has been used for anemia, in Korean medicine. Methods : Sprague-Dawley rats were administered orally with DBT at the dosages of 1,000 mg/kg for 14 days. We daily examined number of deaths, clinical signs, body weights and gross findings during the 14 days. Results : There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and treatment groups. In hematological and biochemical serum parameters, all mean values appear to be within the normal range. Conclusion : These results suggest that DBT dose not induce any significant subacute oral toxicities in Sprague-Dawley rats.