Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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VEGF Expression and Microvessel Density in Salivary Gland Tumor

타액선 종양에서 VEGF의 발현 및 미세혈관밀도의 의의

  • Park Chul-Won (Department of Otolaryngology, College of Medicine, Hanyang University) ;
  • Kim Su-Young (Department of Otolaryngology, College of Medicine, Hanyang University) ;
  • Kim Kyung-Rae (Department of Otolaryngology, College of Medicine, Hanyang University) ;
  • Lee Hyung-Seok (Department of Otolaryngology, College of Medicine, Hanyang University) ;
  • Paik Seung-Sam (Department of Pathology, College of Medicine, Hanyang University) ;
  • Park Yong-Wook (Department of Pathology, College of Medicine, Hanyang University) ;
  • Tae Kyung (Department of Otolaryngology, College of Medicine, Hanyang University)
  • 박철원 (한양대학교 의과대학 이비인후과학교실) ;
  • 김수영 (한양대학교 의과대학 이비인후과학교실) ;
  • 김경래 (한양대학교 의과대학 이비인후과학교실) ;
  • 이형석 (한양대학교 의과대학 이비인후과학교실) ;
  • 백승삼 (한양대학교 의과대학 병리학교실) ;
  • 박용욱 (한양대학교 의과대학 병리학교실) ;
  • 태경 (한양대학교 의과대학 이비인후과학교실)
  • Published : 2005.11.01
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Abstract

Objectives: Angiogenesis is the process of new blood vessel development from preexisting vessel. The growth of tumor is dependent on angiogenesis. This study was aimed to determine the role of the VEGF expression and MVD(microvessel density) in salivary gland tumors and to analyze the correlation between the expression of VEGF/MVD, and clinical manifestation. Material and Methods: We analyzed the expression of VEGF and average MVD and neo-MVD in the 57 cases of salivary gland tumors by immunohistochemistry. Results: VEGF expression was higher in malignant tumors than in benign tumors. Average and neo-MVD were not different in benign tumor and malignant tumor. There was a tendency of positive correlation between VEGF expression and MVD but it was not statistically significant. Stage, T stage and recurrance rate were not correlated with VEGF expression, average-MVD and neo-MVD. Expression of VEGF, average-MVD and neo-MVD were significantly increased in Warthin's tumor compared with pleomorphic adenoma. Conclusion: Overexpression of VEGF has an important role in malignant salivary gland tumors.

Keywords

References

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