Bulletin of the Korean Chemical Society

  • 제26권11호
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  • Pages.1701-1705
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  • 2005
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Rapid Synthesis of Arylpiperazine Derivatives for Imaging 5-HT1A Receptor under Microwave Irradiation

  • Park, Sang-Hyun (Division of Radioisotope Production and Applications, Center for HANARO Application Research, Korea Atomic Energy Research Institute) ;
  • Gwon, Hui-Jeong (Division of Radioisotope Production and Applications, Center for HANARO Application Research, Korea Atomic Energy Research Institute) ;
  • Lee, Hyo-Sun (LG Chemical Ltd./Research Park, Science Park) ;
  • Park, Kyung-Bae (Division of Radioisotope Production and Applications, Center for HANARO Application Research, Korea Atomic Energy Research Institute)
  • 발행 : 2005.11.20
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초록

We have established an efficient method for the synthesis of the arylpiperazine derivatives in which the acylation of 2-aminopyridine, the coupling reaction of the acyl compound with piperazines, and reduction of the arylpiperazines were performed under a microwave irradiation (300 W) to afford the corresponding target compounds in quantitative yields. In all cases, the reaction times were remarkably reduced when compared with those of the conventional method.

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참고문헌

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  1. Application of Microwave Activation Techniques to the N-Alkenyl Protection of Lactams vol.27, pp.2, 2005, https://doi.org/10.5012/bkcs.2006.27.2.286
  2. Rapid Synthesis of Arylpiperazine Derivatives for Imaging 5-HT1A Receptor under Microwave Irradiation. vol.37, pp.14, 2005, https://doi.org/10.1002/chin.200614166
  3. Solvent-free Cleavage of tert-Butyl Esters under Microwave Conditions vol.30, pp.1, 2005, https://doi.org/10.5012/bkcs.2009.30.1.230