• Bulletin of the Korean Chemical Society
• /
• v.26 no.11
• /
• pp.1701-1705
• /
• 2005

We have established an efficient method for the synthesis of the arylpiperazine derivatives in which the acylation of 2-aminopyridine, the coupling reaction of the acyl compound with piperazines, and reduction of the arylpiperazines were performed under a microwave irradiation (300 W) to afford the corresponding target compounds in quantitative yields. In all cases, the reaction times were remarkably reduced when compared with those of the conventional method.

• Bulletin of the Korean Chemical Society
• /
• v.27 no.8
• /
• pp.1189-1193
• /
• 2006

In order to develop radiopharmaceuticals for targeting a serotonin receptor such as $5-HT_{1A}$, histidine-$C_n$-arylpiperazines (AP) (C = alkyl, n = 2, 3, 4) were prepared in five steps with yields of 25%, 37% and 51%, respectively, and radiolabeled with the $[^{99m}Tc(CO)_3(H_2O)+3]^+$. The $^{99m}Tc(CO)_3$-Histidine-Cn-APs were prepared with a high yield (>99%) and characterized as a tridentate complex with a neutral charge to pass through the blood-brain barrier (BBB). The rhenium complexes with $Re(CO)_3$ were also synthesised and comparative experiments were achieved to evaluate the nature of the $^{99m}Tc$ complexes.

• Bulletin of the Korean Chemical Society
• /
• v.32 no.spc8
• /
• pp.2861-2862
• /
• 2011

• Bulletin of the Korean Chemical Society
• /
• v.27 no.10
• /
• pp.1689-1692
• /
• 2006