Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Rapid Synthesis of Arylpiperazine Derivatives for Imaging 5-HT1A Receptor under Microwave Irradiation

  • Park, Sang-Hyun (Division of Radioisotope Production and Applications, Center for HANARO Application Research, Korea Atomic Energy Research Institute) ;
  • Gwon, Hui-Jeong (Division of Radioisotope Production and Applications, Center for HANARO Application Research, Korea Atomic Energy Research Institute) ;
  • Lee, Hyo-Sun (LG Chemical Ltd./Research Park, Science Park) ;
  • Park, Kyung-Bae (Division of Radioisotope Production and Applications, Center for HANARO Application Research, Korea Atomic Energy Research Institute)
  • Published : 2005.11.20
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Abstract

We have established an efficient method for the synthesis of the arylpiperazine derivatives in which the acylation of 2-aminopyridine, the coupling reaction of the acyl compound with piperazines, and reduction of the arylpiperazines were performed under a microwave irradiation (300 W) to afford the corresponding target compounds in quantitative yields. In all cases, the reaction times were remarkably reduced when compared with those of the conventional method.

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References

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