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Preparation and Stabilization of an O/W Emulsion Using Liquid Crystalline Phases

액정상을 이용한 O/W형 에멀젼의 제조 및 제형 안정화에 관한 연구

  • An, Bong-Jeun (Department of Cosmetic Engineering, Daegu Haany University) ;
  • Lee, Jin-Tae (Department of Cosmetic Engineering, Daegu Haany University) ;
  • Lee, In-Chol (Department of Cosmetic Engineering, Daegu Haany University) ;
  • Kwak, Jae-Hoon (Department of Cosmetic Engineering, Daegu Haany University) ;
  • Park, Jung-Mi (Department of Cosmetic Engineering, Daegu Haany University) ;
  • Park, Chan-Ik (School of Chemical Engineering and Institute of Chemical Processes, Seoul National University)
  • 안봉전 (대구한의대학교 화장품공학과) ;
  • 이진태 (대구한의대학교 화장품공학과) ;
  • 이인철 (대구한의대학교 화장품공학과) ;
  • 곽재훈 (대구한의대학교 화장품공학과) ;
  • 박정미 (대구한의대학교 화장품공학과) ;
  • 박찬익 (서울대학교 화학공학과/화학공정신기술연구소)
  • Published : 2004.03.31

Abstract

Liquid crystalline phases were formed from acylglutamate; polyglyceryl-10 myristate and glycerine mixture and they were used as a base material for preparing an O/W emulsion. When an oil phase is added into the liquid crystalline phases, it was inserted into the dispersed liquid crystal droplets rather than stayed outside the liquid crystals, which can be known by the fact that the size of liquid crystal droplets increases with the increasing oil phase content. Along with the increase in the droplet size, the complex modulus increases from 100 to 350 pascals and the loss angle decreases from 60 to 24 degrees, from which it can be known that the increase in the internal phase volume results in the increase in the elastic property of oil in liquid crystalline-phases (O/LC). When the water phase was lastly added into the O/LC phase, the emulsification occurred to form a O/W emulsion and the averaged particle size of the O/W emulsion changes from 22.5nm to 538nm with the addition of water phase. The results from the droplet size measurements and stability tests under accelerated conditions such as high temperature show that the obtained O/W emulsion is very consistent with time.

Keywords

References

  1. C. G. Knight, 'Liposorme, in Physical Structure to Therapeutic Applications' , Elsevier, Amsterdam (1981)
  2. M. J. Ostro, 'Liposome' , Marcel Dekker, New York (1983)
  3. F. Puisieux and J. Delattre, 'Les Liposomes : Applications Therapeutiques', Lavoisier Tec et Doc, Paris (1985)
  4. G. Gregoriadis, J. Wiley, and S. Chichester, 'Liposomes as Drug Carrier s' , Wiley, Chichester (1988)
  5. J. P. Caquet and T. Bernoud, 'Les Cristaux Liquides Dans Les Cosmetiques', Parf. Cosmet. Aromes, 91, 77 (1990)
  6. G. Cioca and L. Calvo, C&T, 105, 57(1990)
  7. M. De Luca, C. Vaution, A, Rabaron, and M. Seiller, STP Pharma Sci, 4, 679 (1988)
  8. S. E. Friberg, J. Soc Cosmet. Chem., 41, 155 (1990)
  9. M. De Luca, J, L. Grossiord, J. M. $M{\'e}dard$, C. Vaution, and M. Seiller, C&T, 105(11), 65 (1990)
  10. G. $Calder{\'o}$, M. J. $Garc{\'i}a$-Celma, C.Solans, and R. Pons, Langmuir, 16(4), 1668 (2000) https://doi.org/10.1021/la990971w
  11. A. D. Bangham, Progress in Biopbysics and Molecular Biology, 18, 29 (1968) https://doi.org/10.1016/0079-6107(68)90019-9
  12. D. G. Kolp and E. S. Lutton, J. Amer. Chem. Soc., 73, 5593 (1951) https://doi.org/10.1021/ja01156a027
  13. K. Tanaka, T. Seto, A. Watanabe, and T. Hayashida, Bull, Inst. Chem. Res., Kyoto Univ. 37, 281 (1959)
  14. S. Fukushima, M. Yamaguchi, and F. Harusawa, J. Colloid and Interface Science. 59(1), 159 (1997)
  15. S. Friberg and P. O. Jansson, J. Colloid and Interface Science, 55(3), 618 (1976)
  16. T. Suzuki, H. Takei, and S. Yamazaki, J. Colloid and Interface Science, 129, 491 (1989) https://doi.org/10.1016/0021-9797(89)90463-3
  17. J. Timmermans, 'Physicochemical Constants of Pure Organic Compounds' Elsevier, New York (1950)
  18. A. Kahn, K. Fontell, and B. Lindman, J. Colloid Interface Sci. 101, 193 (1984) https://doi.org/10.1016/0021-9797(84)90019-5
  19. K. Fontell, Colloid Polym. Sci. 268, 164 (1990)
  20. Hesson Chung, T. W. Kim, Miyun Kwon, I. C. Kwon, and S. Y, Jeong, J. Controlled Release, 71, 339 (2001) https://doi.org/10.1016/S0168-3659(00)00363-1
  21. S. J. Lee, Y. C. Ro, and K. D. Nam, J. Kor. Ind Eng. Chem, 7, 145 (1996)