YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Prevalence of Macrolide Antibiotics Resistance in the Clinical Isolates of Common Respiratory Pathogens

임상분리 호흡기 감염증 원인 균주에서의 Macrolide계 항생물질의 내성

  • Yoon Eun-Jeong (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Ha Jang-Bum (Department of Life Science, University of Seoul) ;
  • Choi Eung-Chil (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Shim Mi-Ja (Department of Life Science, University of Seoul)
  • 윤은정 (서울대학교 약학대학. 종합 약학 연구소) ;
  • 하장범 (서울시립대학교 생명과학과) ;
  • 최응칠 (서울대학교 약학대학. 종합 약학 연구소) ;
  • 심미자 (서울시립대학교 생명과학과)
  • Published : 2004.01.01
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Abstract

The prevalence of resistance to a range of macrolides was determined for clinical isolates of common respiratory pathogens using NCCLS testing methods and interpretative criter ia.71.4% of Streptococcus pneumoniae, 62.3% of Staphylococcus aureus, 50.8% of coagulase-negative staphylococci and 4.4% of Strpetococcus pyogenes were erythromycin resistant. Also, the rates of resistance to other macrolides and clindamycin in these clinical isolates were as high as to eryth -romycin. Almost all of the macrolide-resistant isolates were positive for erm of the methylase gene, or mef of the efflux gene.

Keywords

References

  1. Felmingham, D. : Respiratory pathogens assessing resistance patterns in Europe and the potential role of grepafloxacin as treatment of patients with infections caused by these organisms. J. Antimicrob. Chemother. 45, Topic T2, 1 (2000)
  2. Felmingham, D. : Ralf Rene Reinert Yoichi Hirakata and Arne Rodloff: Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study and comparative in vitro activity of the ketolide, telithromycin. J. Antimicrob. Chemother. 50, suppl. S1, 25 (2002)
  3. Inoue, M., Lee, N. Y., Hong, S. W., Lee, K. and Felmingham, D. : PROTEKT 1999-2000 : a multicentre study of the antibiotic susceptibility of respiratory tract pthogens in Hong Kong, Japan and South Korea. Int. J. Antimicrob. Agents. 23, 44 (2004)
  4. Service, R. F. : Infectious disease: Antibiotics that resist resistance. Science 270, 724 (1995) https://doi.org/10.1126/science.270.5237.724
  5. Felmingham, D. : Antibiotic resistance. Do we need new therapeutic approaches? Chest 108, Suppl. S2, 70s (1995)
  6. Song, J.-H., Jung, S.-I., Ko, K. S., Kim, N. Y., Son, J. S., Chang, H.-H., Ki, H. K., Oh, W. S., Suh, J. Y., Peck, K. R., Lee, N. Y., Yang, Y., Lu, Q., Chongthaleong, A., Kumarasinghe, G., Jamal, F., Kamarulzaman, A., Paraskthi, N., Van, P. H., Carlos, C., So, T., Ng, T. K. and Shibl, A. : High prevalence of antimicrobial resistance among clinical Strepcoccus pneumoniae isolates in Asia (an ANSORP Study). Antimicrob. Agents Chemother. 48, 2101 (2004) https://doi.org/10.1128/AAC.48.6.2101-2107.2004
  7. Kim, H. B., Jang, H.-C., Nam, H. J., Lee, Y. S., Kim, B. S., Park, W. B., Lee, K. D., Choi, Y. J., Park, S. W., Oh, M.-D., Kim, E.-C. and Choe, K. W. : In vitro activities of 28 antimicrobial agents against Staphylococcus aureus isolates from tertiarycare hospitals in Korea: a Nationwide survey. Antimicrob. Agents Chemother. 48, 1124 (2004)
  8. Jacobs, M. R., Felmingham, D., Appelbaum, P. C., Gruneberg, R. N. and the Alexander Project Group : The alexander project 1998${\sim}$2000 : susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents. J. Antimicrob. Chemother. 52, 229 (2003)
  9. Felmingham, D., Gruneberg, R. N. and the Alexander Project Group: The alexander project 1996${\sim}$1997 : latest susceptibility data from this international study of bacterial pathogens from community-acquired lower respiratory tract infections. J. Antimicrob. Chemother. 45, 191 (2000)
  10. Uh, Y., Jang, I. H., Hwang, G. Y., Lee, M. K., Yoon, K. J. and Kim, H. Y. : Antimicrobial chemotherapy pattern and macrolide resistance genes of ${\beta}$-hemolytic streptococci in Korea. Antimicrob. Agents Chemother. 48, 2716 (2004) https://doi.org/10.1128/AAC.48.7.2716-2718.2004
  11. Felmingham, D. : The need for antimicrobial resistance surveillance. J. Antimicrob. Chemother. 50, Suppl. S1, 1 (2002)
  12. Masterton, R. G. : Surveillance studies: how can they help the management of infection? J. Antimicrob. Chemother. 46, Topic T2, 53 (2000)
  13. National Committee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Document M7A5. National Committee for Clinical Laboratory Standards, Wayne, Pa. 11. NCCLS (2000)
  14. Lim, J.-A, Kwon, A.-R., Kim, S.-K., Chong, Y., Lee, K. and Choi, E.-C. : Prevalence of resistance to macrolide, lincosamide and streptogramin antibiotics in Gram-positive cocci isolated in a Korean hospital. J. Antimicrob. Chemother. 49, 489 (2002) https://doi.org/10.1093/jac/49.3.489
  15. Carbon C, Poole MD : The role of newer macrolides in the treatment of community acquired respiratory tract infection. A review of experimental and clinical data. J. Chemother. 11, 107 (1999)
  16. Farrell, D. J., Morrissey, I., Sarah Bakker Louise Morris, Buckridge, S. and Felmingham, D. : Molecular epidemiology of multiresistant Strepcocus pneumoniae with both erm(B)- and mef(A)-mediated macrolide resistance. J. Clinic. Mocrob. 42, 764 (2004) https://doi.org/10.1128/JCM.42.2.764-768.2004
  17. Buxbaum, A., Forsthuber, S., Graninger, W. and Georgopoulos, A. : Comparative activity of telithromycin against typical community-acquired respiratory pathogens. J. Antimicrob. Chemother. 52, 371 (2003) https://doi.org/10.1093/jac/dkg359
  18. Felmingham, D. : Evolving resistance patterns in community-acquired respiratory tract pathogens: first results from the PROTEKT global surveillance study. Prospective resistant organism tracking and epidemiology for the Ketolide Teli-thromycin. J. Infect. 44, Suppl. A, 3 (2002)