Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Protective effect of Cynomorii Herba extract on $H_2O_2$-induced cytotoxicity

Hydrogen Peroxide에 의해 유도된 남성생식세포의 세포독성에 미치는 소양(銷陽)의 효과

  • Oh Myung-Sook (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim Do-Rim (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Yang Woong-Mo (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Chang Mun-Seog (Dept. of Medicine, Division of Newborn Medicine, Children's Hospital and Harvard Medical School) ;
  • Park Soo-Yeon (Research institute of Physical education, Kyung Hee Univ.) ;
  • Kang Soon-Ah (Dept. of Applied Biology & Chemistry, Konkuk University) ;
  • Park Seong-Kyu (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • 오명숙 (경희대학교 한의과대학 방제학교실) ;
  • 김도림 (경희대학교 한의과대학 방제학교실) ;
  • 양웅모 (경희대학교 한의과대학 방제학교실) ;
  • 장문석 (하버드대학교 의과대학 소아병원) ;
  • 박수연 (경희대학교 체육과학연구소) ;
  • 강순아 (건국대학교 응용생물화학과 생명분자정보학센터) ;
  • 박성규 (경희대학교 한의과대학 방제학교실) ;
  • Published : 2004.12.30
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Abstract

The purpose of this study is to examine the protective effect of Cynomorii herba on $H_2O_2$-induced cytotoxicity in male germ cells. The effects were studied by a modified MTT assay. Hydrogen peroxide significantly induced cytotoxicity in GC-1 spg cells, and co-treatment or pre-treatment of Cynomorii herba extract has reduced the cytotoxicity in a dose dependant manner. These results suggest that Cynomorii herba extract increases the survival rate of GC-1 spg cells through the antioxidant effect against $H_2O_2$-induced cytotoxicity.

Keywords

References

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