생물정신의학 (Korean Journal of Biological Psychiatry)
- 제10권1호
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- Pages.80-84
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- 2003
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
양극성 장애 환자에서 CTLA-4 유전자 다형성
Polymorphism of CTLA-4 Gene in Patients with Bipolar Disorder
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전태연
(가톨릭대학교 의과대학 정신과학교실) ;
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이경욱
(가톨릭대학교 의과대학 정신과학교실) ;
- 이혁재 (가톨릭대학교 의과대학 정신과학교실) ;
- 배치운 (가톨릭대학교 의과대학 정신과학교실) ;
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채정호
(가톨릭대학교 의과대학 정신과학교실) ;
- 박원명 (가톨릭대학교 의과대학 정신과학교실) ;
- 김광수 (가톨릭대학교 의과대학 정신과학교실)
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Jun, Tae-Youn
(Department of Psychiatry, College of Medicine The Catholic University of Korea) ;
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Lee, Kyoung-Uk
(Department of Psychiatry, College of Medicine The Catholic University of Korea) ;
- Lee, Hyuk-Jae (Department of Psychiatry, College of Medicine The Catholic University of Korea) ;
- Pae, Chi-Un (Department of Psychiatry, College of Medicine The Catholic University of Korea) ;
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Chae, Jeong-Ho
(Department of Psychiatry, College of Medicine The Catholic University of Korea) ;
- Bahk, Won-Myong (Department of Psychiatry, College of Medicine The Catholic University of Korea) ;
- Kim, Kwang-Soo (Department of Psychiatry, College of Medicine The Catholic University of Korea)
- 발행 : 2003.06.30
초록
Objective : Bipolar disorder is known to have strong genetic background and cellular immune activation. Based on the hypothesis that abnormalities of normal inhibitory control of T cell immunity can contribute to the pathophysiology of bipolar disorder, we investigated the relationship between the first exon at position +49(A/G) polymorphism of cytotoxic T lymphocyte antigen 4(CTLA4) gene and bipolar disorder. Method : Among the Korean patients diagnosed as bipolar disorder according to DSM-IV, 90 patients without serious medical illness, neurologic illness, hormonal disorder, or concomitant mental illness were selected. The normal control group consisted of 149 age-and sex-matched subjects without current or past history of autoimmune diseases or mental disorder. DNA was extracted from whole blood and the exon 1 region of CTLA-4 gene was amplified by polymerase chain reaction. Gene typing was performed using single strand conformation polymorphism. Results : There were no significant differences in genotype frequencies of G/G, G/A, and A/A between the patients with bipolar disorder and the control group(48.9% vs 46.3%, 44.4% vs 39.6%, and 6.7% vs 14.1%, respectively). There were no significant differences in allelic frequencies of G and A between the patients with bipolar disorder and the control group(71.1% vs 66.1%, and 28.9% vs 33.9%, respectively). Conclusion : This study did not show the association of exon 1 polymorphism of CTLA-4 gene with bipolar disorder.