생물정신의학 (Korean Journal of Biological Psychiatry)
- 제10권1호
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- Pages.70-79
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- 2003
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
주요 우울증에서 혈중 Cytokine과 임상적 호전과의 관계
The Relationship between the Serum Cytokine and Clinical Improvement in Major Depressive Disorder
- 김현철 (한림대학교 의과대학 춘천성심병원 정신과학교실) ;
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이상규
(한림대학교 의과대학 춘천성심병원 정신과학교실) ;
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김도훈
(한림대학교 의과대학 춘천성심병원 정신과학교실) ;
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손봉기
(한림대학교 의과대학 춘천성심병원 정신과학교실)
- Kim, Hyon Chul (Department of Psychiatry, Hallym University College of Medicine) ;
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Lee, Sang Kyu
(Department of Psychiatry, Hallym University College of Medicine) ;
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Kim, Do Hoon
(Department of Psychiatry, Hallym University College of Medicine) ;
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Son, Bong Ki
(Department of Psychiatry, Hallym University College of Medicine)
- 발행 : 2003.06.30
초록
Object : Currently, the alteration of cytokine system has been known to play an important role in regard to depressive symptom. We focused on the relationship between immunological parameters and clinical improvement in major depressive disorder. Method : Data were collected on 26 patients with major depressive disorder using a 8-week prospective follow-up design. After 8-week treatment period with fluoxetine, patients were classified into a response group and a non-response group according to their psychopathological outcome as evaluated by Hamilton Depression Rating Scale. The differences of the immunological parameters between pre-treatment phase and post-treatment phase were compared among patients. The difference of those was also compared within each phase among them. The relationship between socio-demographic variables, depression, cytokine, mononuclear cells was examined by correlation analysis. Multiple regression analyses were performed to explore the predictors of clinical improvement of major depressive disorder. Result : Pre-treatment levels of IL-
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