IMMUNE NETWORK
- Volume 3 Issue 2
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- Pages.145-149
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- 2003
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Apo-1/Fas (CD95) Gene Polymorphism in Korean Knee Osteoarthritis Patients
한국인 무릎 골 관절염 환자들의 임상 양상과 Apo-1/Fas (CD95) 유전자 다형성과의 상관관계에 관한 연구
- Hong, Seung-Jae (Department of Internal Medicine, College of Medicine, KyungHee University) ;
- Yang, Hyung-In (Department of Internal Medicine, College of Medicine, KyungHee University) ;
- Yim, Sung-Vin (Kohwang Medical Research Institute, KyungHee University) ;
- Chung, Joo-Ho (Kohwang Medical Research Institute, KyungHee University) ;
- Jung, Young-Ok (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
- Kim, Ho-Youn (Department of Internal Medicine, College of Medicine, The Catholic University of Korea)
- 홍승재 (경희대학교 의과대학 내과학교실) ;
- 양형인 (경희대학교 의과대학 내과학교실) ;
- 임성빈 (경희대학교 고황의학연구소) ;
- 정주호 (경희대학교 고황의학연구소) ;
- 정영옥 (가톨릭대학교 의과대학 내과학교실) ;
- 김호연 (가톨릭대학교 의과대학 내과학교실)
- Published : 2003.06.30
Abstract
Background: Apoptosis has been implicated in pathogenesis of various disease. Apo-1/Fas (CD95) is one of the main pathway of apoptosis. To examine the possible relationship between Apo-1/Fas (CD95) and primary knee osteoarthritis, MvaI restriction length polymorphism (RFLP) in human Apo-1/Fas (CD95) gene was assessed. Methods: Genotype and allele frequencies in promoter region in the Apo-1/Fas (CD95) gene were studied by PCR-RFLP in 226 Korean controls and 148 Korean patients with primary knee osteoarthritis. Results: No statistically significant difference in the genotypic distribution and allelic frequencies was found between the control and the knee oateoarthritis patients. But in the severe grade (grade 3, 4) Kellgren-Lawrence score patients, the frequency of