The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Contralateral Heterotropic Electroacupuncture Modulates Formalin Induced Pain in the Rat

거자법에 의한 전침자극이 백서의 formalin 유발 통증에 대한 억제기전

  • 류영수 (원광대학교 한의과대학 신경정신과학교실)
  • Published : 2003.06.01
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Abstract

Objectives : In this study, we investigated the effect and pathway of contralateral heterotropic electroacupuncture (EA) on pain induced by fonualin in rats. Methods : Acu-points in the right forepaws, HT 7 and PC 7 were stimulated with 3~4mA, 2ms, and 10Hz after 5% formalin (50ul) s.c. injection to the left hind paw. In addition, it was investigated whether the dorsolateral funiculus (DLF), known to be related the descending inhibition, mediates analgesic effects of the contralateral heterotropic EA or whether administration of naltrexone, an opioid antagonist, blocks the effect of EA. Results : The results showed that contralateral heterotropic electroacupuncture (EA) inhibited late phase (63.311.7%) of pain induced by fonualin in the behavioral test, but sham-EA had little effect on pain behavior (85.616.8%) and no analgesic effects after transection of the dorsolateral funiculus (95.718.7%). The pretreatment of naltrexone (10mg/kg, i.p.) could not inhibit the analgesic effects of EA on formalin-induced pain behavior (70.713.1%). Also,EA suppressed formalin injection induced expression of cFos like protein (cFL) in the dorsal homo but not sham-EA. Suppressed expressions of cFL in the spinal cord were eliminated after transection of the ipsilateral dorsolateral funiculus at T10-11 leve1s. However, pretreatment of naltrexone could not prevent the suppressive expressions of cFL at the spinal cord. Conclusions : These results suggest that the analgesic effect of contralateral heterotropic electroacupuncture may be modulated through the dorsolateral funiculus constituting the descending inhibition.

Keywords

References

  1. 黃帝內經 素問(校勘直譯) 홍원식(譯)
  2. 전국한의학 학술대회 논문집 중풍환자에 있어서 거자법에 대한 유용성 검토 문상관(외 4인)
  3. J. Neurophysiol. v.54 T2-T5 spinothalamic neurons projecting to medial thalamus with viscerosomatic input Ammons, W. S.;Girardot, M.-N.;Foreman, R. D.
  4. Pain v.51 no.1 The formalin test: an evaluation of the method Tjolsen A;Berge OG;Hunskaar S;Rosland JH;Hole K
  5. J. Neurochem. v.51 Extracellular amino acid concentration ein the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation Skilling S.R.;Smullin D.H.;Beitz A.J.;Larson A.A.
  6. Neuroscience v.30 Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ Kuraishi D.;Hirota N.;Sato Y.;Hanashima N.;Takagi H.;Satoh M.
  7. Neuropharmacology v.33 Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat Haley J.E.;Kickenson A.H.;Schachter M.
  8. Nature v.328 Induction of c-fos-like protein in spinal cord neurons following sensory stimulation Hunt, S.P.;Pini, A.;Evan, G.
  9. 鍼灸經緯 楊維傑
  10. The J. Korean Acupuncture & Moxibustion Society v.12 no.1 Study of acupuncture treatment on the sprain NK. Cho;KS. Kim
  11. British Journal of Anaesthesia no.75 Descending control of Pain J.A. Stamford
  12. Pain v.6 Diffuse noxious inhibitory controls (DNIC). I. Effects on dosal horn convergent neurones in the rat D. Le Bars;A.H. Dickenson;J.M. Besson
  13. Neurosci. Lett. v.58 Propriospinal fibers reaching the lumbar enlargement in the rat Mene´trey, D.;De Pommery, J.;Roudier, F.
  14. Science v.150 Pain mechanism: a new theory Merzack R;Wall P.D.
  15. Annual Review of Neuroscience v.7 Endogenous pain control systems Basbaum, A.I.;Fields, H.L.
  16. J. Neurophysiol. v.76 Enhanced descending modulation of nociception in rats with persistent hindpaw inflammation K. Ren;R. Dubner
  17. Neuroscience v.58 Effects of descending inhibitory systems on the c-Fos expression in the rat spinal cord during formalin-induced noxious stimulation R.X. Zhang;R. Wang;J.Y. Chen;J.T. Qiao
  18. Pain v.6 Diffuse noxious inhibitory controls (DNIC). I. Effects on dosal horn convergent neurones in the rat D. Le Bars;A.H. Dickenson;J.M. Besson
  19. Adv. Pain Res. Therapy v.22 Opioids and diffuse noxious inhibitory control (DNIC) in the rat D. Le Bars;D. Bouhassira;L. Villanueva
  20. Neuroscience v.37 no.3 Acupuncture and Diffuse Noxious Inhibitory Controls: Naloxone-reversible depression of activities of trigeminal convergent neurons Z. Bing;L. Villanueva;D. Le Bars
  21. J. Neurophysiol. v.67 Evidence that C1 and C2 propriospinal neurons mediate the inhibitory effects of viscerosomatic spinal afferent input on. primate spinothalamic tract neurons S.F. Hobbs;U.T. Oh;M.J. Chandler;Q.-G. Fu;D.C. Bolser;R.D. Foreman
  22. Neurosci. Lett. v.58 Propriospinal fibers reaching the lumbar enlargement in the rat Mene´trey, D.;De Pommery, J.;Roudier, F.
  23. Brain Research Bulletin v.47 no.1 Propriospinal neurons in the C1-C2 spinal segments project to the L5-S1 segments of the rat spinal cord Kenneth E. Miller;Vickie D. Douglas;A. Brent Richards;Margaret J. Chandler;Robert D. Foreman
  24. Br. J. Pharmacol. v.90 Afferent c-fiber and A delta activity in models of inflammation Heapy C.C.;Jamieson A.;Russell N.J.W.
  25. Pain v.30 Subcutaneous formalin-induced activity of dorsal horn neuron in the rat: differential response to an intrathecal opiate administered pre or post formalin Dickenson AH;Sullivan AF
  26. Brain Res. v.506 Differential effects of exitatory amino acid antagonist on dorsal horn nociceptive neurones in the rat Dickenson AH;Sullivan AF
  27. J. Neurochem. v.51 Extracellular amino acid concentration ein the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation Skilling S.R.;Smullin D.H.;Beitz A.J.;Larson A.A.
  28. Neuroscience v.30 Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ Kuraishi D.;Hirota N.;Sato Y.;Hanashima N.;Takagi H.;Satoh M.
  29. Neuropharmacology v.33 Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat Haley J.E.;Kickenson A.H.;Schachter M.
  30. Molec. Brain Res. v.6 Temporal analysis of increases in c-fos preprodynorphin and preproenkephalin mRNAs in ra spinal cord Draisci G.;Iadarolia M.J.
  31. Nature v.328 Induction of c-Fos like protein in spinal cord neurons following sensory stimulation Hunt S.P.;Pini A.;Evan G.
  32. Neuroscience v.48 C-Fos expression in rat lumbar spinal cord during the development of adjuvant-induced arthritis Abbadie C.;Besson J.-M.
  33. Neuron v.10 Molecular mechanism of pain: serotonin receptor agonists trigger transactivation by c-Fos of the prodynophin gene in spinal cord neurons Lucas JJ;Mellstrom B;Colado MI;Naranjo JR
  34. Acupunct Electrother Res. v.17 no.1 Alterations of spinal dorsal horn substance P following electroacupuncture analgesia-a study of the formalin test with immunohistochemistry and densitometry Du J;He L
  35. The effect of Bee Venom Acupuncture into ST36 on Formalin induced Pain Behavior and Neuronal Activity in the Spinal Cord Yun-Kyoung Yim
  36. science v.216 Organization of endorgenous opiate and non-opiate pain control system Watkins, L.R.;Mayer, D.J.
  37. Pain v.16 no.1 Naloxone fails to reverse pain thresholds elevated by acupuncture: acupuncture analgesia reconsidered Chapman CR;Benedetti C;Colpitts YH;Gerlach R
  38. Brain Res. Bull. v.29 no.5 Descending pain inhibitory system involved in acupuncture analgesia Takeshige C.;Sato T.;Mera T.;Hisamitsu T.;Fang J.
  39. Brain Res. Bull. v.29 Descending pain inhibitory system involved in acupuncture analgesia Takeshige, C.;Sato, T.;Mera, T.;Hisamitsu, T.;Fang, J.
  40. J. Neurophysiol. v.74 Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla Fields, H.L.;Malick, A.;Burstein, R.