Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Cholinesterase Inhibitory Activity of Two Farnesylacetone Derivatives from the Brown Alga Sargassum sagamianum

  • Ryu, Geon-Seek (Regional Research Center, Hanbat National University) ;
  • Park, Soo-Hee (Department of Chemical Technology, Hanbat National University) ;
  • Kim, Eun-Sook (Department of Chemical Technology, Hanbat National University) ;
  • Choi, Byoung-Wook (Department of Chemical Technology, Hanbat National University) ;
  • Ryu, Shi-Yong (Korea Research Institute of Chemical Technology) ;
  • Lee, Bong-Ho (Department of Chemical Technology, Hanbat National University)
  • Published : 2003.10.01
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Abstract

Two known farnesylacetone derivatives (1 and 2) were isolated from the Korean brown alga Sargassum sagamianum off Jeju Island, Korea. Compounds 1 and 2 were identified as (5E,10Z)-6, 10, 14-trimethylpentadeca-5, 10-dien-2, 12-dione and (5E,9E,13E)-6, 10,4-trimethylpentadeca-5,9,13-trien-2,12-dione, respectively, by comparison with the literature data. Compounds 1 and 2 showed moderate acetylcholinesterase and butyrylcholinesterase inhibitory activities with $IC_{50}$ values of 65.0∼48.0 and 34.0∼23.0 $\muM$, respectively.

Keywords

References

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