• Title/Summary/Keyword: Sragassum sagamianum

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Cholinesterase Inhibitory Activity of Two Farnesylacetone Derivatives from the Brown Alga Sargassum sagamianum

  • Ryu, Geon-Seek;Park, Soo-Hee;Kim, Eun-Sook;Choi, Byoung-Wook;Ryu, Shi-Yong;Lee, Bong-Ho
    • Archives of Pharmacal Research
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    • v.26 no.10
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    • pp.796-799
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    • 2003
  • Two known farnesylacetone derivatives (1 and 2) were isolated from the Korean brown alga Sargassum sagamianum off Jeju Island, Korea. Compounds 1 and 2 were identified as (5E,10Z)-6, 10, 14-trimethylpentadeca-5, 10-dien-2, 12-dione and (5E,9E,13E)-6, 10,4-trimethylpentadeca-5,9,13-trien-2,12-dione, respectively, by comparison with the literature data. Compounds 1 and 2 showed moderate acetylcholinesterase and butyrylcholinesterase inhibitory activities with $IC_{50}$ values of 65.0∼48.0 and 34.0∼23.0 $\muM$, respectively.