Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Protective Effect of Diallyl disulfide(DADS) from Garlic Extract on Noise Induced Hearing Loss in the Guinea pigs

소음으로 인한 청력소실에 대한 마늘 추출물 diallyl disulfide(DADS)의 효과

  • Yoon, Min-Young (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Won-Kwang University) ;
  • Cho, Nam-Geun (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Won-Kwang University) ;
  • Hwang, Woo-Jun (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Won-Kwang University) ;
  • Jang, Chul-Ho (Department of otorhinolaryngology College of medicine, Won-Kwang University)
  • 윤민영 (원광대학교 부속익산한방병원 침구과교실) ;
  • 조남근 (원광대학교 부속익산한방병원 침구과교실) ;
  • 황우준 (원광대학교 부속익산한방병원 침구과교실) ;
  • 장철호 (원광대학교 의과대학 이비인후과학교실)
  • Received : 2002.03.07
  • Accepted : 2002.03.18
  • Published : 2002.04.20
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Abstract

Objective : The purpose of this study is to investigate the protective effect of DADS on the noise induced hearing loss Methods : Twenty healthy guinea pigs (DADS pretreated group and control) were exposed to 100dB a collected environmental noise for 9 hours. An auditory evoked brainstem response (ABR) threshold was measured before and after a noise exposure. For morphological study, cochlea was studied by scanning electron microscope (SEM). Results : The DADS pretreated group showed statistically significant less changes in ABR threshold and SEM findings compared the control group. Conclusion : From these results suggest that the DADS from garlic may have a protective effect in noise induced hearing loss.

Keywords

Acknowledgement

Supported by : 원광대학교