Journal of Acupuncture Research
- Volume 19 Issue 2
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- Pages.92-104
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- 2002
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
The effect of Bee Venom on type II Collagen-induced Arthritis
봉독약침이 제2형 콜라겐유도 관절염에 미치는 영향
- Kim, Tae-Woo (Department of Acupuncture & Moxibustion, College of Oriental Medicine in Kyung-Hee University) ;
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Choi, Do-Young
(Department of Acupuncture & Moxibustion, College of Oriental Medicine in Kyung-Hee University) ;
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Lee, Jae-Dong
(Department of Acupuncture & Moxibustion, College of Oriental Medicine in Kyung-Hee University)
- Received : 2002.02.01
- Accepted : 2002.03.19
- Published : 2002.04.20
Abstract
Objective : Bee venom (BV) has traditionally been used in Oriental medicine to relieve pain and to treat inflammatory disease such as rheumatoid arthritis (RA). Autoimmunity to type II collagen (CII) may involve in the pathogenesis of RA. This study was performed to evaluate the effect of BV on type II collagen induced arthritis (CIA) with the naked eye, a immunohistochemical method and the examination of histology. Method : Male mice were immunized by subcutaneously injection of an
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