The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Antipyretic Effect of Rhizoma Cimicifugae in a Rat Model of LPS-Induced Fever

Lipopolysaccharide에 의해 유발된 발열에 있어서 승마의 해열효과

  • 권일호 (원광대학교 한의과대학 외관과학교실) ;
  • 김남권 (원광대학교 한의과대학 외관과학교실) ;
  • 강학천 (원광대학교 한의과대학 외관과학교실) ;
  • 임홍진 (원광대학교 한의과대학 외관과학교실) ;
  • 김진만 (원광대학교 한의과대학 외관과학교실)
  • Published : 2002.12.01
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Abstract

Objective: In this study, we investigated the effects of Rhizoma Cimicifugae (RC) on the induction of nitric oxide (NO) in RAW 264.7 murine macrophages treated with lipopolysaccharide (LPS). Methods: We examined whether RC have an antipyretic effect by inhibition of COX and/or NOS in fever that is evoked by an intraperitoneal injection of LPS in rats. Results: 1. RC inhibited NO metabolites produced by activated murine macrophage in a dose-dependent manner. 2. RC had an antipyretic effect in a dose-dependent manner in LPS-induced fever. 3. RC inhibited levels of both COX-2 protein and iNOS protein increased by the treatment of LPS in brain tissues as well as brain blood vessels. 4. There were no changes in proteins of nNOS/COX-1. Conclusions: RC has an antipyretic effect by attenuating the level of iNOS and COX-2 protein.

Keywords

References

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