The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Kumsooyukkun-jeon on Asthma Induced by Ovalbumin in Mice

금수육군전이 Ovalbumin으로 수발된 Mice의 천식에 미치는 영향

  • 김춘석 (경산대학교 한의과대학 폐계내과학교실) ;
  • 최해윤 (경산대학교 한의과대학 폐계내과학교실) ;
  • 김종대 (경산대학교 한의과대학 폐계내과학교실)
  • Published : 2002.09.01
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Abstract

Objectives : To study the effects of Kumsooyukkun-jeon on asthma. Methods : Asthma was induced to Balb/c mice with ovalbumin using the method of Hatfield et al. We measured the histological profiles of lung and trachea, numbers of cellular compartments in the bronchoalveolar lavage fluid (BALF), numbers and morphology of the mast cells in the trachea, numbers of mucous-secretory cells in the bronchus, morphology of the bronchus, ultramicroscopical appearance of surface of trachea and number of cilia and mucous-secretory cells by scanning electron microscope. Results : 1. Hypertrophy of mucous membrane of trachea and bronchus and bronchioles in the lung, peritracheal, peribronchus and peribronchiolar inflammatory cell infiltration, and mucoid exudate deposition the lumen were observed in control groups but these phenomena were recovered in the Kumsooyukkun-jeon groups. 2. Cellular compartments including neutrophil and eosinophil were increased in the BALF of control groups but these phenomena were recovered in the Kumsooyukkun-jeon groups. 3. Degranulation and decrease of the numbers of mast cells were detected in the trachea of control groups. However, these phenomena were recovered in the Kumsooyukkun-jeon groups. 4. Shedding, decrease of cilia cell and increase of mucous-secretory cells in the surface of the trachea were measured in control groups but these phenomena were recovered in the Kumsooyukkun-jeon groups. Conclusions : It is considered that Kumsooyukkun-jeon has somewhat favorable effects on asthma.

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References

  1. 임상호흡기학 v.2 韓鏞徹
  2. 알레르기와 韓方 v.1 丁奎萬
  3. 定喘湯이 알레르기성 천식의 呼吸 樣相과 氣管粘膜의 好酸球浸潤에 미치는 影響. 王中權
  4. CIBA원색도해의학총서 v.1 이영현;김수성;권영무;김성자;구정태
  5. 소아과학회지 v.9 no.1 천식에 관한 문헌적 고찰. 金潤子;金璋顯
  6. 諸病源候論 v.1 巢元方
  7. 醫門寶鑑 v.1 周命新
  8. 臨證指南醫案 v.1 葉天士
  9. 景岳全書 v.1 張介賓
  10. 麥門冬湯이 알레르기 천식의 呼吸樣相과 氣管組織에 미치는 影響. 柳旭相
  11. 金水六君煎이 흰쥐의 SO${_2}$에 의한 呼吸器損傷에 미치는 影響. 李承蓮
  12. 한국한의학연구소논문집 v.2 no.1 금수육군전이 SO${_2}$에 의한 흰쥐의 호흡기조직손상에 미치는 영향. 이승룡;박동일
  13. 對譯證脈, 方藥合編 v.6 黃度淵
  14. Am J Physiol(Lung Cell MoL Physiol 17). v.273 Intercellular adhesion molecule-l-deficient mice have normal antibody responses, but impaired leukocyte recruitment. Hatfield CA;Brashler JR;Winterrowd GE;Bell FP;Griffin RL;Fidler SF; Kolbasa KP;Shull KL;Mobley JL;Richards IM;Chin JE.
  15. Am Rev Respir Dis. v.137 Development of a prolonged eosinophil-rich inflammatory leukocyte infiltration in the guinea pig asthmatic response to ovalbumin inhalation. Dunn CJ;Elliot GA;Osteven JA;Richard IM.
  16. Animal tissue techniques. Humason GL.
  17. 東醫臨床方劑學 v.1 尹吉榮
  18. 東醫方劑와 處方解說 v.1 尹用甲
  19. 그림으로 설명한 병리학 v.2 금주섭
  20. Immunology v.1 Roitt I;Brostoff J;Male D.
  21. J Allergy Clin Immunol. v.54 no.4 Late asthmatic responses induced by ragweed pollen allergen. Robertson DG;Kerigan AT;Hargreave FE.
  22. Br. J. Phamac. v.90 Inhibition of IgE dependent histamine releas from human dispersed lung mast cells by anti-allergic drugs and salbutamol. Church MK;Hiroi J.
  23. Am Rev Respir Dis. v.132 Influence of albuterol, cromolyn sodium ipratropium bromide on the airway and circulating mediator response to allergic bronchial provocation in asthma. Howarth PH;Durbam SR;Lee TH;Kay AB;Church MK;Holgate ST.
  24. J Allergy Clin Immunol. v.79 no.5 Comparative effects of inhaled salbutamol, sodium cromoglycate and beclomethasone dipropionate on allergen-induced early asthmatic response and increased bronchial responsiveness to histamine. Cockroft DW;Murdock KY.
  25. Am Rev Respir Dis v.148 Efficacy and safety of inhaled corticosteroids in asthma. Barns P;Pederson S.
  26. Korean Journal of Allergy. v.17 no.1 동물천식모형. 최인선
  27. Am J Respir Cell Mol Biol. v.13 Effect of dexamethasone on antigen-induced high molecular weight glycoconjugate secretionin allergic guinea pigs Savoie C;Plant M;Zwikker M;Van Staden CJ;Boulet L;Chan CC;Rodger IW;Pon DJ.
  28. Ovalbumin에 의한 기니픽 천식 유발시 폐의 조직 병리학적 변화에 미치는 상백피의 영향. 蘇秉埈
  29. Respiration. v.65 Effects of inhaled cyclosporin on the rat air way(histologic and bronchoalveolar lavage assessment). Ceyhan Y;Sungur M;Celikel CA;Ceilikel T.
  30. Arerugi. v.44 Inhibitory effect of low molecular weight heparin on the bronchoconstriction in ovalbumin-sensitized guinea pigs after antigen exposure. Maeda H;Yahata T;Satouchi M;Takenaka K;Yokoyama M.
  31. 한국이비인후과학회지 v.39 알레르기가 유발된 기니픽 비점막에서 호산구 침윤과 상피 손상과의 관계. 홍순관
  32. Thorax. v.53 An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Temelkovski J;Hogan SP;Shepherd DP;Foster PS;Kumar RK.
  33. Clinical and Experimental Allergy. v.28 Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma. Eber E;Uhlig T;McMenamin C;Sly PD.
  34. J Pharmacal Exp Ther. v.280 no.1 The influence of endogenous catecholamines on the inhibitory effects of rolipram against early- and late-phase response to antigen in the guinea pig. Underwood DC;Matthews JK;Osborn RR;Bochnowicz S;Torphy TJ.
  35. Eur J Pharmacol. v.293 Bronchoconstric- tion and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice. Hessel EM;Van Oosterhout AJ;Hofsta CL;De Bie JJ;Garssen J;Van Loveren H;Verheyen AK;Savelkoul HF;Nijkamp FP.
  36. Am J Respir Cell Mol Biol. v.14 Lung inflammation and epithelial changes in a murine model of atopic asthma. Blyth DI;Pedrick MS;Savage TJ;Hessel EM;Fattah D.