The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Protective Effects of Jaummi-dan (Ciyinmei-dan) against Skin Photoaging in Hairless Mouse Model and UVB-induced Damage in Human Fibroblasts

한방미용제제(자음미단)의 Hairless Mouse Model에서의 피부광노화 억제 및 섬유아세포의 UVB손상 저해효과

  • 김선영 ((주)태평양 기술연구원 의약건강연구소) ;
  • 안덕균 (경희대학교 한의과대학) ;
  • 박성규 (경희대학교 한의과대학) ;
  • 이진영 ((주)태평양 기술연구원 의약건강연구소) ;
  • 김완기 ((주)태평양 기술연구원 의약건강연구소) ;
  • 심영철 ((주)태평양 기술연구원 의약건강연구소) ;
  • 이상준 ((주)태평양 기술연구원 의약건강연구소)
  • Published : 2002.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : To investigate the photoprotective effects and efficacy of Jaummi-dan (Ciyinmei-dan) on UV damage to animal skin/fibroblast cultures. Methods and Results : Hairless mice were orally administered Jaummi-dan (Ciyinmei-dan) extract and irradiated with UV for four weeks. In the Jaummi-dan (Ciyinmei-dan) treated group, a better skin appearance and less wrinkles were observed when compared to the control group. In addition, immunostaining for type 1 pN collagen showed that the amount of collagen deposition was higher in the Jaummi-dan (Ciyinmei-dan) treated group. The interstitial collagenase was measured in the cultured medium of fibroblasts after UVB irradiation using ELISA for MMP-l. Jaummi-dan (Ciyinmei-dan) treatment resulted in a significant decrease in MMP-1 secretion compared to the UVB-irradiated, untreated group. Conclusions : The results of our study indicate that orally administered Jaummi-dan (Ciyinmei-dan) seems to have photoprotective effects on UV damaged hairless mouse skin partly due to an inhibitory effect on collagen breakdown.

Keywords

References

  1. 미용중의학 황비리
  2. J Invest Dermatol. v.100 Antioxidant defensemechanisms in murine epidermis and dermis and their responses to ultraviolet light. Shindo Y;Witt E;Packer L.
  3. Photodamage. Prevention of photodamage with sunprotection and sunscreens. Lowe NJ;Friedlander J.;Gilchrest BA,(eds.)
  4. Am J Clin Nutr. v.73 Nutritional skin care:health effects of micronutrients and fatty acids. Boelsma E;Hendriks H;Roza L.
  5. Eur J Biochem. v.134 Monoclonal antibody speciflc for the amino-terminal cleavage site of procollagen type 1. Foellmer HG;Kawahara K;Madri JA;Furthmayr H;Timpl R;Tuderman LA.
  6. Clinica Chemica Acta. v.219 A one-step sandwich enzyme immuno-assay for human matrix metalloproteinase 1 (interstitial collagenase) using monoclonal antibodies. Zhang J;Fujimoto N;Iwata K;Sakai T;Okada Y;Hayakawa T
  7. 실용미용중약 劉大有;貢濟宇
  8. Br J Dermatol. v.140 A histological study of human wrinkle structures :comparison between sun-exposed areas of the face, with or without wrinkles, and sun-protected areas. Contet-Audonneau JL;Jeanmaire C;Pauly G.
  9. Am J Pathol. v.158 Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro. Varani J;Spearman D;Perone P;Fligiel SE, Datta SC;Wang ZQ;Shao Y;Kang S;Fisher GJ;Voorhees JJ.
  10. 東醫寶鑑 許浚
  11. Am J Clin Nutr. v.71 Tronnier H;Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Stahl W;Heinrich U;Jungman H;Sies H
  12. J Am Acad Dermatol. v.38 Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E). Eberlein-Konig B;Placzek M;Przybilla B.
  13. Arch dermatol. v.36 Green Tea and Skin. Katiyar SK;Ahmad N.
  14. Photochem Photobiol. v.46 An Animal model of solar-aged skin: histological, physical and visible changes in UV-irradiated hairless mouse skin. Bisset DL;Hannon DP;Orr TV.
  15. Photochem Photobiol. v.56 The hairless mouse model of photoaging: evaluation of the relationship between dermal elastin, collagen. skin thickness and wrinkles. Moloney SJ;Edmonds SH;Giddens LD;Learn DB.
  16. Photodamage. Biochemical and molecularchanges in photoaged skin. Yaar M;Gilchrest BA.;Gilchrest BA(eds.)
  17. J Derm Sci. v.12 The relationship between quantitative changes in collagen and formation of wrinkles on hairless mouse skin afterchronic UV irradiation. Takema Y;Hattori M;Aizawa K.
  18. J Dermartol Sci. v.9 Photoaging from an oxidative standpoint. Miyachi Y.
  19. Nature. v.379 Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Fisher GJ;Datta SC;Talwar HS;Wang ZQ;Varani J;Kang S;Voorhees JJ.
  20. J Photoch Photobio B. v.41 The use of endogenous antioxidants to improve photoprotection. Steenvoorden DP;Hencgouwen GM
  21. 한국식품영양과학회지 v.28 no.5 사물절편의 이화학적 품질특성 및 항산화 효과. 김윤선;임영희;왕수경;윤숙자;박춘란
  22. 한국식품과학회지 v.33 no.1 다류원료 식물류 물 추출물의 항산화 효과. 김미혜;김명철;박종석;김종욱;이종욱