An Association Study of COMT Gene Polymorphism with Korean Alcoholism

한국인 알코올리즘과 Catechol-O-methyltransferase(COMT) 유전자 다형성의 연합

  • Kim, Min-Jung (Department of Clinical Pathology, Hanyang University Hospital) ;
  • Yang, Byung-Hwan (Department of Neuropsychiatry, College of Medicine and The Medical Health Research Insititute, Hanyang University) ;
  • Lee, Jung-Sik (Yong-In Mental Hospital) ;
  • Chai, Young-Gyu (Department of Biochemistry and Molecular Biology, Hanyang University) ;
  • Park, Taek-Kyu (Department of Chemistry, College of Science, Kon-Kuk University)
  • 김민정 (한양대학교병원 임상병리과) ;
  • 양병환 (한양대학교 정신건강연구소 및 의과대학 신경정신과학교실) ;
  • 이정식 (용인정신병원) ;
  • 채영규 (한양대학교 생화학 및 분자생물학과) ;
  • 박택규 (건국대학교 화학과)
  • Published : 2001.06.30


An association study with Korean alcoholic patients(n=50) and normal controls(n=53) was performed to find the relationship between catechol-O-methyltransferase(COMT) gene polymorphism and alcoholism using polymerase chain reaction-restriction fragment length polymorphism. When we compared the allele and genotype frequencies of Nla III COMT gene polymorphism in alcoholism and normal controls, there was no significant difference between two groups. Our results do not support an association between the Nla III polymorphism of COMT gene and alcoholism.